Parvovirus B19 (human erythroviruses)

Kevin Brown*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Parvoviruses are small, 20-25 nm icosahedral viruses (see Figure 5.1, encapsidating a linear single stranded DNA genome of approximately 4000-6000 nucleotides. The family (Parvoviridae) is divided into two subfamilies based on their host species and viral coding strategies, the Parvovirinae that infect vertebrates, including fish, birds, reptiles and mammals, and the Densovirinae that infect insects. The Parvovirinae are similarly divided into five genera, Parvovirus, Dependovirus, Erythrovirus, Bocavirus and Amdovirus, based on the number of promoters, their transcription map, the similarity of the 5' and 3' terminal repeat sequences, and their sequence homology (Fauquet et al., 2005). Several different parvoviruses have been identified in humans, including adeno-associated viruses (AAVs, Parv4 (Jones et al., 2005) and Parv5 (Fryer et al., 2006, human bocavirus (Allander et al., 2005, and parvovirus B19 (B19V) (Cossart et al., 1975, but only parvovirus B19 has definitively been shown to be a human pathogen. B19V was the first member to be described and is the type species of the genus Erythrovirus. The virus has a genome of 5596 nucleotides, consisting of an internal coding sequence of 4830 nucleotides, flanked by identical terminal repeat sequences at the 5' and 3' end of 383 nucleotides which form the imperfect palindrome and hairpin structures necessary for DNA replication and encapsidation.

Original languageEnglish
Title of host publicationTransfusion Microbiology
PublisherCambridge University Press
Number of pages8
ISBN (Electronic)9780511545245
ISBN (Print)9780521453936
Publication statusPublished - 1 Jan 2008

Bibliographical note

Publisher Copyright:
© Cambridge University Press 2008 and 2009.


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