Paraproteinaemia after allo-SCT, association with alemtuzumab-based conditioning and CMV reactivation

P. Medd, S. Littlewood, R. Danby, R. Malladi, R. Clifford, D. Wareham, K. Jeffery, B. Ferry, D. Roberts, A. Peniket, T. Littlewood*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Paraproteinaemia following allo-SCT is common. We analysed 91 consecutive patients undergoing allo-SCT; conditioning included alemtuzumab in 42% of the patients. Paraproteinaemia incidence at 2 years was 32%. In univariate analysis paraproteinaemia was associated with unrelated donor, age, recipient seropositivity for CMV and alemtuzumab conditioning (hazard ratio (HR) 3.93, P = 0.0006). Paraproteinaemia was not associated with haematological diagnosis; disease status at transplant; varicella zoster, herpes simplex or EBV serology; reduced-intensity vs myeloablative conditioning or GVHD. CMV reactivationmore frequent in alemtuzumab recipientswas associated with paraproteinaemia (HR 7.52, P < 0.0001). In multivariate analysis, only increasing age (HR 1.04 per year, P = 0.048) and CMV reactivation (HR 5.74, P = 0.001) were significantly associated with paraproteinaemia. Alemtuzumab without CMV reactivation, however, resulted in significantly more paraproteinaemia, suggesting an effect that is independent of CMV reactivation. OS was poorer in patients with paraproteinaemia (HR 2.54, P = 0.04) and relapse increased (HR 2.38, P = 0.087). Paraproteinaemia was not significantly independently associated with decreased survival on multivariate analysis. Post transplant paraproteinaemia is associated with CMV reactivation, is more frequent in alemtuzumab-conditioned transplants and is not associated with improved OS.

Original languageEnglish
Pages (from-to)993-999
Number of pages7
JournalBone Marrow Transplantation
Volume46
Issue number7
DOIs
Publication statusPublished - Jul 2011
Externally publishedYes

Bibliographical note

Funding Information:
We would like to thank Kevin Paddon for assistance with laboratory data collection and the staff of the Immunology Laboratory at the Churchill Hospital Oxford for performing serum electrophoresis and immunofixation assays. This work was funded by the NIHR Biomedical Research Centre Programme.

Keywords

  • alemtuzumab
  • allogeneic transplantation
  • CMV
  • monoclonal gammopathy
  • paraprotein

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