Outbreak of Ralstonia pickettii associated with contamination of saline products distributed internationally, the United Kingdom, 2024

Mike Saunders; Amy Weaver; Rebecca Stretch; D. Jeyaratnam; Mariyam Mirfenderesky; David Elliott; Charlotte Patterson; David Williams; Dervla T.D. Kenna; Jack Turton; Karen L. Osman; Jane F. Turton; Colin S. Brown; J. W.T. Elston

doi:10.2807/1560-7917.ES.2024.29.27.2400384

Outbreak of Ralstonia pickettii associated with contamination of saline products distributed internationally, the United Kingdom, 2024

Mike Saunders, Amy Weaver, Rebecca Stretch, D. Jeyaratnam, Mariyam Mirfenderesky, David Elliott, Charlotte Patterson, David Williams, Dervla T.D. Kenna, Jack Turton, Karen L. Osman, Jane F. Turton, Colin S. Brown, J. W.T. Elston^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

We describe an outbreak of Ralstonia pickettii in the United Kingdom, with isolates genetically indistinguishable from a 2023 Australian outbreak linked to internationally distributed saline solutions. Confirmed cases (n=3) had bacteraemia, clinically relevantinfection,indwellingvenouslinesandfrequent healthcare contact. Multi-stakeholder intervention was required including product recall and risk communications. We recommend a low threshold for investigating clusters of Ralstonia species and similar opportunistic pathogens, considering contaminated product sources. Effective mitigation requires multi-agency partnership and international collaboration.

Original language	English
Article number	2400384
Journal	Eurosurveillance
Volume	29
Issue number	27
DOIs	https://doi.org/10.2807/1560-7917.ES.2024.29.27.2400384
Publication status	Published - 4 Jul 2024

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© 2024 European Centre for Disease Prevention and Control (ECDC). All rights reserved.

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10.2807/1560-7917.ES.2024.29.27.2400384

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Saunders, M., Weaver, A., Stretch, R., Jeyaratnam, D., Mirfenderesky, M., Elliott, D., Patterson, C., Williams, D., Kenna, D. T. D., Turton, J., Osman, K. L., Turton, J. F., Brown, C. S., & Elston, J. W. T. (2024). Outbreak of Ralstonia pickettii associated with contamination of saline products distributed internationally, the United Kingdom, 2024. Eurosurveillance, 29(27), Article 2400384. https://doi.org/10.2807/1560-7917.ES.2024.29.27.2400384

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abstract = "We describe an outbreak of Ralstonia pickettii in the United Kingdom, with isolates genetically indistinguishable from a 2023 Australian outbreak linked to internationally distributed saline solutions. Confirmed cases (n=3) had bacteraemia, clinically relevantinfection,indwellingvenouslinesandfrequent healthcare contact. Multi-stakeholder intervention was required including product recall and risk communications. We recommend a low threshold for investigating clusters of Ralstonia species and similar opportunistic pathogens, considering contaminated product sources. Effective mitigation requires multi-agency partnership and international collaboration.",

author = "Mike Saunders and Amy Weaver and Rebecca Stretch and D. Jeyaratnam and Mariyam Mirfenderesky and David Elliott and Charlotte Patterson and David Williams and Kenna, {Dervla T.D.} and Jack Turton and Osman, {Karen L.} and Turton, {Jane F.} and Brown, {Colin S.} and Elston, {J. W.T.}",

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doi = "10.2807/1560-7917.ES.2024.29.27.2400384",

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Saunders, M, Weaver, A, Stretch, R, Jeyaratnam, D, Mirfenderesky, M, Elliott, D, Patterson, C, Williams, D, Kenna, DTD, Turton, J, Osman, KL, Turton, JF, Brown, CS & Elston, JWT 2024, 'Outbreak of Ralstonia pickettii associated with contamination of saline products distributed internationally, the United Kingdom, 2024', Eurosurveillance, vol. 29, no. 27, 2400384. https://doi.org/10.2807/1560-7917.ES.2024.29.27.2400384

TY - JOUR

T1 - Outbreak of Ralstonia pickettii associated with contamination of saline products distributed internationally, the United Kingdom, 2024

AU - Saunders, Mike

AU - Weaver, Amy

AU - Stretch, Rebecca

AU - Jeyaratnam, D.

AU - Mirfenderesky, Mariyam

AU - Elliott, David

AU - Patterson, Charlotte

AU - Williams, David

AU - Kenna, Dervla T.D.

AU - Turton, Jack

AU - Osman, Karen L.

AU - Turton, Jane F.

AU - Brown, Colin S.

AU - Elston, J. W.T.

PY - 2024/7/4

Y1 - 2024/7/4

N2 - We describe an outbreak of Ralstonia pickettii in the United Kingdom, with isolates genetically indistinguishable from a 2023 Australian outbreak linked to internationally distributed saline solutions. Confirmed cases (n=3) had bacteraemia, clinically relevantinfection,indwellingvenouslinesandfrequent healthcare contact. Multi-stakeholder intervention was required including product recall and risk communications. We recommend a low threshold for investigating clusters of Ralstonia species and similar opportunistic pathogens, considering contaminated product sources. Effective mitigation requires multi-agency partnership and international collaboration.

AB - We describe an outbreak of Ralstonia pickettii in the United Kingdom, with isolates genetically indistinguishable from a 2023 Australian outbreak linked to internationally distributed saline solutions. Confirmed cases (n=3) had bacteraemia, clinically relevantinfection,indwellingvenouslinesandfrequent healthcare contact. Multi-stakeholder intervention was required including product recall and risk communications. We recommend a low threshold for investigating clusters of Ralstonia species and similar opportunistic pathogens, considering contaminated product sources. Effective mitigation requires multi-agency partnership and international collaboration.

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DO - 10.2807/1560-7917.ES.2024.29.27.2400384

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AN - SCOPUS:85197753636

SN - 1025-496X

VL - 29

JO - Eurosurveillance

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IS - 27

M1 - 2400384

ER -

Outbreak of Ralstonia pickettii associated with contamination of saline products distributed internationally, the United Kingdom, 2024

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