Oseltamivir-resistant pandemic influenza a (H1N1) 2009 viruses in Spain

Juan Ledesma; Diego Vicente; Francisco Pozo; Gustavo Cilla; Sonia Pérez Castro; Jonathan Suárez Fernández; Mercedes Pérez Ruiz; José María Navarro; Juan Carlos Galán; Mirian Fernández; Jordi Reina; Amparo Larrauri; María Teresa Cuevas; Inmaculada Casas; Pilar Pérez Breña

doi:10.1016/j.jcv.2011.04.008

Oseltamivir-resistant pandemic influenza a (H1N1) 2009 viruses in Spain

Juan Ledesma^*, Diego Vicente, Francisco Pozo, Gustavo Cilla, Sonia Pérez Castro, Jonathan Suárez Fernández, Mercedes Pérez Ruiz, José María Navarro, Juan Carlos Galán, Mirian Fernández, Jordi Reina, Amparo Larrauri, María Teresa Cuevas, Inmaculada Casas, Pilar Pérez Breña

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Background: Pandemic influenza A (H1N1) 2009 virus appeared in Spain on April 25, 2009 for the first time. This new virus was adamantane-resistant but it was sensitive to neuraminidase (NA) inhibitors oseltamivir and zanamivir. Objectives: To detect oseltamivir-resistant pandemic influenza A (H1N1) 2009 viruses by the Spanish Influenza Surveillance System (SISS) and a possible spread of oseltamivir-resistant viruses in Spain since starting of the pandemic situation. Study design: A total of 1229 respiratory samples taken from 413 severe and 766 non-severe patients with confirmed viral detection of pandemic influenza A (H1N1) 2009 viruses from different Spanish regions were analyzed for the specific detection of the H275Y mutation in NA between April 2009 and May 2010. Results: H275Y NA substitution was found in 8 patients infected with pandemic influenza A (H1N1) 2009 viruses collected in November and December 2009 and in January 2010. All oseltamivir-resistant viruses were detected in severe patients (8/413, 1.93%) who previously received treatment with oseltamivir. Six of these patients were immunocompromised. Conclusion: In Spain, the number of oseltamivir-resistant pandemic influenza A (H1N1) 2009 viruses is until now very low. No evidence for any spread of oseltamivir-resistant H1N1 viruses is achieved in our Country.

Original language	English
Pages (from-to)	205-208
Number of pages	4
Journal	Journal of Clinical Virology
Volume	51
Issue number	3
DOIs	https://doi.org/10.1016/j.jcv.2011.04.008
Publication status	Published - Jul 2011
Externally published	Yes

Keywords

H275Y mutation
Influenza
Neuraminidase
Oseltamivir-resistance

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jcv.2011.04.008

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Ledesma, J., Vicente, D., Pozo, F., Cilla, G., Castro, S. P., Fernández, J. S., Ruiz, M. P., Navarro, J. M., Galán, J. C., Fernández, M., Reina, J., Larrauri, A., Cuevas, M. T., Casas, I., & Breña, P. P. (2011). Oseltamivir-resistant pandemic influenza a (H1N1) 2009 viruses in Spain. Journal of Clinical Virology, 51(3), 205-208. https://doi.org/10.1016/j.jcv.2011.04.008

@article{fbd87948a07842a2801a1c828b7aebbd,

title = "Oseltamivir-resistant pandemic influenza a (H1N1) 2009 viruses in Spain",

abstract = "Background: Pandemic influenza A (H1N1) 2009 virus appeared in Spain on April 25, 2009 for the first time. This new virus was adamantane-resistant but it was sensitive to neuraminidase (NA) inhibitors oseltamivir and zanamivir. Objectives: To detect oseltamivir-resistant pandemic influenza A (H1N1) 2009 viruses by the Spanish Influenza Surveillance System (SISS) and a possible spread of oseltamivir-resistant viruses in Spain since starting of the pandemic situation. Study design: A total of 1229 respiratory samples taken from 413 severe and 766 non-severe patients with confirmed viral detection of pandemic influenza A (H1N1) 2009 viruses from different Spanish regions were analyzed for the specific detection of the H275Y mutation in NA between April 2009 and May 2010. Results: H275Y NA substitution was found in 8 patients infected with pandemic influenza A (H1N1) 2009 viruses collected in November and December 2009 and in January 2010. All oseltamivir-resistant viruses were detected in severe patients (8/413, 1.93\%) who previously received treatment with oseltamivir. Six of these patients were immunocompromised. Conclusion: In Spain, the number of oseltamivir-resistant pandemic influenza A (H1N1) 2009 viruses is until now very low. No evidence for any spread of oseltamivir-resistant H1N1 viruses is achieved in our Country.",

keywords = "H275Y mutation, Influenza, Neuraminidase, Oseltamivir-resistance",

author = "Juan Ledesma and Diego Vicente and Francisco Pozo and Gustavo Cilla and Castro, \{Sonia P{\'e}rez\} and Fern{\'a}ndez, \{Jonathan Su{\'a}rez\} and Ruiz, \{Mercedes P{\'e}rez\} and Navarro, \{Jos{\'e} Mar{\'i}a\} and Gal{\'a}n, \{Juan Carlos\} and Mirian Fern{\'a}ndez and Jordi Reina and Amparo Larrauri and Cuevas, \{Mar{\'i}a Teresa\} and Inmaculada Casas and Bre{\~n}a, \{Pilar P{\'e}rez\}",

year = "2011",

month = jul,

doi = "10.1016/j.jcv.2011.04.008",

language = "English",

volume = "51",

pages = "205--208",

journal = "Journal of Clinical Virology",

issn = "1386-6532",

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TY - JOUR

T1 - Oseltamivir-resistant pandemic influenza a (H1N1) 2009 viruses in Spain

AU - Ledesma, Juan

AU - Vicente, Diego

AU - Pozo, Francisco

AU - Cilla, Gustavo

AU - Castro, Sonia Pérez

AU - Fernández, Jonathan Suárez

AU - Ruiz, Mercedes Pérez

AU - Navarro, José María

AU - Galán, Juan Carlos

AU - Fernández, Mirian

AU - Reina, Jordi

AU - Larrauri, Amparo

AU - Cuevas, María Teresa

AU - Casas, Inmaculada

AU - Breña, Pilar Pérez

PY - 2011/7

Y1 - 2011/7

N2 - Background: Pandemic influenza A (H1N1) 2009 virus appeared in Spain on April 25, 2009 for the first time. This new virus was adamantane-resistant but it was sensitive to neuraminidase (NA) inhibitors oseltamivir and zanamivir. Objectives: To detect oseltamivir-resistant pandemic influenza A (H1N1) 2009 viruses by the Spanish Influenza Surveillance System (SISS) and a possible spread of oseltamivir-resistant viruses in Spain since starting of the pandemic situation. Study design: A total of 1229 respiratory samples taken from 413 severe and 766 non-severe patients with confirmed viral detection of pandemic influenza A (H1N1) 2009 viruses from different Spanish regions were analyzed for the specific detection of the H275Y mutation in NA between April 2009 and May 2010. Results: H275Y NA substitution was found in 8 patients infected with pandemic influenza A (H1N1) 2009 viruses collected in November and December 2009 and in January 2010. All oseltamivir-resistant viruses were detected in severe patients (8/413, 1.93%) who previously received treatment with oseltamivir. Six of these patients were immunocompromised. Conclusion: In Spain, the number of oseltamivir-resistant pandemic influenza A (H1N1) 2009 viruses is until now very low. No evidence for any spread of oseltamivir-resistant H1N1 viruses is achieved in our Country.

AB - Background: Pandemic influenza A (H1N1) 2009 virus appeared in Spain on April 25, 2009 for the first time. This new virus was adamantane-resistant but it was sensitive to neuraminidase (NA) inhibitors oseltamivir and zanamivir. Objectives: To detect oseltamivir-resistant pandemic influenza A (H1N1) 2009 viruses by the Spanish Influenza Surveillance System (SISS) and a possible spread of oseltamivir-resistant viruses in Spain since starting of the pandemic situation. Study design: A total of 1229 respiratory samples taken from 413 severe and 766 non-severe patients with confirmed viral detection of pandemic influenza A (H1N1) 2009 viruses from different Spanish regions were analyzed for the specific detection of the H275Y mutation in NA between April 2009 and May 2010. Results: H275Y NA substitution was found in 8 patients infected with pandemic influenza A (H1N1) 2009 viruses collected in November and December 2009 and in January 2010. All oseltamivir-resistant viruses were detected in severe patients (8/413, 1.93%) who previously received treatment with oseltamivir. Six of these patients were immunocompromised. Conclusion: In Spain, the number of oseltamivir-resistant pandemic influenza A (H1N1) 2009 viruses is until now very low. No evidence for any spread of oseltamivir-resistant H1N1 viruses is achieved in our Country.

KW - H275Y mutation

KW - Influenza

KW - Neuraminidase

KW - Oseltamivir-resistance

UR - https://www.scopus.com/pages/publications/79959195235

U2 - 10.1016/j.jcv.2011.04.008

DO - 10.1016/j.jcv.2011.04.008

M3 - Article

C2 - 21592854

AN - SCOPUS:79959195235

SN - 1386-6532

VL - 51

SP - 205

EP - 208

JO - Journal of Clinical Virology

JF - Journal of Clinical Virology

IS - 3

ER -

Oseltamivir-resistant pandemic influenza a (H1N1) 2009 viruses in Spain

Abstract

Keywords

UN SDGs

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