TY - JOUR
T1 - Oseltamivir-resistant influenza virus A (H1N1), Europe, 2007-08 season
AU - Meijer, Adam
AU - Lackenby, Angie
AU - Hungnes, Olav
AU - Lina, Bruno
AU - Van Der Werf, Sylvie
AU - Schweiger, Brunhilde
AU - Opp, Matthias
AU - Paget, John
AU - Van De Kassteele, Jan
AU - Hay, Alan
AU - Zambon, Maria
PY - 2009/4
Y1 - 2009/4
N2 - In Europe, the 2007-08 winter season was dominated by influenza virus A (H1N1) circulation through week 7, followed by influenza B virus from week 8 onward. Oseltami-vir-resistant influenza viruses A (H1N1) (ORVs) with H275Y mutation in the neuraminidase emerged independently of drug use. By country, the proportion of ORVs ranged from 0% to 68%, with the highest proportion in Norway. The average weighted prevalence of ORVs across Europe increased gradually over time, from near 0 in week 40 of 2007 to 56% in week 19 of 2008 (mean 20%). Neuraminidase genes of ORVs possessing the H275Y substitution formed a homogeneous subgroup closely related to, but distinguishable from, those of oseltamivir-sensitive influenza viruses A (H1N1). Minor variants of ORVs emerged independently, indicating multiclonal ORVs. Overall, the clinical effect of ORVs in Europe, measured by influenza-like illness or acute respiratory infection, was unremarkable and consistent with normal seasonal activity.
AB - In Europe, the 2007-08 winter season was dominated by influenza virus A (H1N1) circulation through week 7, followed by influenza B virus from week 8 onward. Oseltami-vir-resistant influenza viruses A (H1N1) (ORVs) with H275Y mutation in the neuraminidase emerged independently of drug use. By country, the proportion of ORVs ranged from 0% to 68%, with the highest proportion in Norway. The average weighted prevalence of ORVs across Europe increased gradually over time, from near 0 in week 40 of 2007 to 56% in week 19 of 2008 (mean 20%). Neuraminidase genes of ORVs possessing the H275Y substitution formed a homogeneous subgroup closely related to, but distinguishable from, those of oseltamivir-sensitive influenza viruses A (H1N1). Minor variants of ORVs emerged independently, indicating multiclonal ORVs. Overall, the clinical effect of ORVs in Europe, measured by influenza-like illness or acute respiratory infection, was unremarkable and consistent with normal seasonal activity.
UR - https://www.scopus.com/pages/publications/65149097183
U2 - 10.3201/eid1504.181280
DO - 10.3201/eid1504.181280
M3 - Article
AN - SCOPUS:65149097183
SN - 1080-6040
VL - 15
SP - 552
EP - 560
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 4
ER -
