TY - JOUR
T1 - Origins and properties of Mycobacterium tuberculosis isolates in London
AU - Dale, Jeremy W.
AU - Bothamley, Graham H.
AU - Drobniewski, Francis
AU - Gillespie, Stephen H.
AU - McHugh, Timothy D.
AU - Pitman, Richard
N1 - Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2005/6
Y1 - 2005/6
N2 - Using similarities of IS6110 banding patterns, isolates of Mycobacterium tuberculosis from a population-based study in London were assigned to 12 large groups termed 'superfamilies' (sfams). Analysis of patient data showed a marked geographical association in the distribution of these sfams. In particular, isolates from patients born in Europe were from different sfams than those born elsewhere, indicating that there had been relatively little transmission of tuberculosis in London from immigrant communities into the endogenous population. Multivariate analysis showed that certain sfams were significantly associated with pulmonary rather than extrapulmonary disease, or with sputum smear negativity, independently of country of birth or ethnicity, suggesting that the properties of the infecting organism play a role in the nature of the disease process.
AB - Using similarities of IS6110 banding patterns, isolates of Mycobacterium tuberculosis from a population-based study in London were assigned to 12 large groups termed 'superfamilies' (sfams). Analysis of patient data showed a marked geographical association in the distribution of these sfams. In particular, isolates from patients born in Europe were from different sfams than those born elsewhere, indicating that there had been relatively little transmission of tuberculosis in London from immigrant communities into the endogenous population. Multivariate analysis showed that certain sfams were significantly associated with pulmonary rather than extrapulmonary disease, or with sputum smear negativity, independently of country of birth or ethnicity, suggesting that the properties of the infecting organism play a role in the nature of the disease process.
UR - http://www.scopus.com/inward/record.url?scp=20344403749&partnerID=8YFLogxK
U2 - 10.1099/jmm.0.45959-0
DO - 10.1099/jmm.0.45959-0
M3 - Article
C2 - 15888467
AN - SCOPUS:20344403749
SN - 0022-2615
VL - 54
SP - 575
EP - 582
JO - Journal of Medical Microbiology
JF - Journal of Medical Microbiology
IS - 6
ER -
