Operative vaginal delivery and post-partum infection

Olaa Mohamed-Ahmed, Kim Hinshaw, Marian Knight*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)


During the past decade, there has been an increase in the awareness of infections associated with pregnancy and delivery. The most significant cause of post-partum infection is caesarean section; 20–25% of operations are followed by wound infections, endometritis or urinary tract infections. Approximately 13% of women in the UK undergo operative vaginal delivery (OVD) with forceps or vacuum, which is also associated with an increased risk of infection, estimated at 0.7%–16% of these deliveries. Despite this, previous reviews have identified only one small trial of antibiotic prophylaxis in 393 women and concluded that there was insufficient evidence to support the routine use of prophylactic antibiotics after OVD. The ANODE trial, a multicentre, blinded, placebo-controlled trial from the UK, is due to report findings from more than 3400 women in 2019 and will be the largest study to date of antibiotic prophylaxis following OVD.

Original languageEnglish
Pages (from-to)93-106
Number of pages14
JournalBest Practice and Research: Clinical Obstetrics and Gynaecology
Publication statusPublished - Apr 2019
Externally publishedYes

Bibliographical note

Funding Information:
MK and KH are both co-investigators of the ANODE trial and funded by a grant from the National Institute for Health Research . The authors have no other conflicts to declare.

Publisher Copyright:
© 2018


  • Fever
  • Infection
  • Operative vaginal delivery
  • Post-partum
  • Pregnancy
  • Sepsis


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