Operational guidance for radiation emergency response organisations in Europe for using biodosimetric tools developed in eu multibiodose project

Alicja Jaworska; Elizabeth A. Ainsbury; Paola Fattibene; Carita Lindholm; Ursula Oestreicher; Kai Rothkamm; Horst Romm; Hubert Thierens; Francois Trompier; Philippe Voisin; Anne Vral; Clemens Woda; Andrzej Wojcik

doi:10.1093/rpd/ncu294

Operational guidance for radiation emergency response organisations in Europe for using biodosimetric tools developed in eu multibiodose project

Alicja Jaworska^*, Elizabeth A. Ainsbury, Paola Fattibene, Carita Lindholm, Ursula Oestreicher, Kai Rothkamm, Horst Romm, Hubert Thierens, Francois Trompier, Philippe Voisin, Anne Vral, Clemens Woda, Andrzej Wojcik

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

In the event of a large-scale radiological emergency, the triage of individuals according to their degree of exposure forms an important initial step of the accident management. Although clinical signs and symptoms of a serious exposure may be used for radiological triage, they are not necessarily radiation specific and can lead to a false diagnosis. Biodosimetry is a method based on the analysis of radiation-induced changes in cells of the human body or in portable electronic devices and enables the unequivocal identification of exposed people who should receive medical treatment. The MULTIBIODOSE (MBD) consortium developed and validated several biodosimetric assays and adapted and tested them as tools for biological dose assessment in a mass-casualty event. Different biodosimetric assays were validated against the 'gold standard' of biological dosimetry-the dicentric assay. The assays were harmonised in such a way that, in an emergency situation, they can be run in parallel in a network of European laboratories. The aim of this guidance is to give a concise overview of the developed biodosimetric tools as well as how and when they can be used in an emergency situation.

Original language	English
Pages (from-to)	165-169
Number of pages	5
Journal	Radiation Protection Dosimetry
Volume	164
Issue number	1-2
DOIs	https://doi.org/10.1093/rpd/ncu294
Publication status	Published - 1 Apr 2015

Bibliographical note

Funding Information:
This work was supported by the European Union within the 7th Framework Programme, theme SECURITY (grant agreement no 241536).

Funding Information:
One such concept was developed in the MULTIBIODOSE (multi-disciplinary biodosimetric tools to manage high-scale radiological casualties) project, www.multibiodose.eu. This capability project was funded by the European Commission under the theme SECURITY and was completed in 2013. The main goal of the project was to adapt a variety of biodosimetric tools to mass-casualty scenarios and to use them in a concerted way by using common software to integrate and report dose estimates. At the end of the project, a network of laboratories was created that are able to cope with dose assessment in case of a high number of potentially exposed people.

Publisher Copyright:
© The Author 2014.

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10.1093/rpd/ncu294

Cite this

Jaworska, A., Ainsbury, E. A., Fattibene, P., Lindholm, C., Oestreicher, U., Rothkamm, K., Romm, H., Thierens, H., Trompier, F., Voisin, P., Vral, A., Woda, C., & Wojcik, A. (2015). Operational guidance for radiation emergency response organisations in Europe for using biodosimetric tools developed in eu multibiodose project. Radiation Protection Dosimetry, 164(1-2), 165-169. https://doi.org/10.1093/rpd/ncu294

Jaworska, Alicja ; Ainsbury, Elizabeth A. ; Fattibene, Paola ; Lindholm, Carita ; Oestreicher, Ursula ; Rothkamm, Kai ; Romm, Horst ; Thierens, Hubert ; Trompier, Francois ; Voisin, Philippe ; Vral, Anne ; Woda, Clemens ; Wojcik, Andrzej. / Operational guidance for radiation emergency response organisations in Europe for using biodosimetric tools developed in eu multibiodose project. In: Radiation Protection Dosimetry. 2015 ; Vol. 164, No. 1-2. pp. 165-169.

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abstract = "In the event of a large-scale radiological emergency, the triage of individuals according to their degree of exposure forms an important initial step of the accident management. Although clinical signs and symptoms of a serious exposure may be used for radiological triage, they are not necessarily radiation specific and can lead to a false diagnosis. Biodosimetry is a method based on the analysis of radiation-induced changes in cells of the human body or in portable electronic devices and enables the unequivocal identification of exposed people who should receive medical treatment. The MULTIBIODOSE (MBD) consortium developed and validated several biodosimetric assays and adapted and tested them as tools for biological dose assessment in a mass-casualty event. Different biodosimetric assays were validated against the 'gold standard' of biological dosimetry-the dicentric assay. The assays were harmonised in such a way that, in an emergency situation, they can be run in parallel in a network of European laboratories. The aim of this guidance is to give a concise overview of the developed biodosimetric tools as well as how and when they can be used in an emergency situation.",

author = "Alicja Jaworska and Ainsbury, {Elizabeth A.} and Paola Fattibene and Carita Lindholm and Ursula Oestreicher and Kai Rothkamm and Horst Romm and Hubert Thierens and Francois Trompier and Philippe Voisin and Anne Vral and Clemens Woda and Andrzej Wojcik",

note = "Funding Information: This work was supported by the European Union within the 7th Framework Programme, theme SECURITY (grant agreement no 241536). Funding Information: One such concept was developed in the MULTIBIODOSE (multi-disciplinary biodosimetric tools to manage high-scale radiological casualties) project, www.multibiodose.eu. This capability project was funded by the European Commission under the theme SECURITY and was completed in 2013. The main goal of the project was to adapt a variety of biodosimetric tools to mass-casualty scenarios and to use them in a concerted way by using common software to integrate and report dose estimates. At the end of the project, a network of laboratories was created that are able to cope with dose assessment in case of a high number of potentially exposed people. Publisher Copyright: {\textcopyright} The Author 2014.",

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Jaworska, A, Ainsbury, EA, Fattibene, P, Lindholm, C, Oestreicher, U, Rothkamm, K, Romm, H, Thierens, H, Trompier, F, Voisin, P, Vral, A, Woda, C & Wojcik, A 2015, 'Operational guidance for radiation emergency response organisations in Europe for using biodosimetric tools developed in eu multibiodose project', Radiation Protection Dosimetry, vol. 164, no. 1-2, pp. 165-169. https://doi.org/10.1093/rpd/ncu294

Operational guidance for radiation emergency response organisations in Europe for using biodosimetric tools developed in eu multibiodose project. / Jaworska, Alicja; Ainsbury, Elizabeth A.; Fattibene, Paola; Lindholm, Carita; Oestreicher, Ursula; Rothkamm, Kai; Romm, Horst; Thierens, Hubert; Trompier, Francois; Voisin, Philippe; Vral, Anne; Woda, Clemens; Wojcik, Andrzej.

In: Radiation Protection Dosimetry, Vol. 164, No. 1-2, 01.04.2015, p. 165-169.

Research output: Contribution to journal › Article › peer-review

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AU - Ainsbury, Elizabeth A.

AU - Fattibene, Paola

AU - Lindholm, Carita

AU - Oestreicher, Ursula

AU - Rothkamm, Kai

AU - Romm, Horst

AU - Thierens, Hubert

AU - Trompier, Francois

AU - Voisin, Philippe

AU - Vral, Anne

AU - Woda, Clemens

AU - Wojcik, Andrzej

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Operational guidance for radiation emergency response organisations in Europe for using biodosimetric tools developed in eu multibiodose project

Abstract

Bibliographical note

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