Novel in vitro functional assays for the determination of anthrax toxin components.

B. Hallis; Nigel Silman; S. Noonan; R. Baker; A. D. Roberts; C. P. Quinn; T. Marks; C. Wiblin; Graham Lloyd; A. Robinson; Michael Hudson

Novel in vitro functional assays for the determination of anthrax toxin components.

B. Hallis^*
, Nigel Silman
, S. Noonan
, R. Baker
, A. D. Roberts
, C. P. Quinn
, T. Marks
, C. Wiblin
, Graham Lloyd
, A. Robinson
, Michael Hudson

^*Corresponding author for this work

Countermeasures Development & Evaluation Project Managers

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The characterisation and evaluation of the UK licensed human anthrax vaccine depends on several in vivo tests that determine its safety and potency. Assays for the determination of functionally active and/or immunoreactive toxin components and S-layer proteins have been developed and applied to the characterisation of anthrax vaccine. These technologies may support production of consistent and effective vaccines, and may ultimately reduce the requirements for in vivo testing.

Original language	English
Pages (from-to)	321-326
Number of pages	6
Journal	Developments in biologicals
Volume	111
Publication status	Published - 2002

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cite this

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abstract = "The characterisation and evaluation of the UK licensed human anthrax vaccine depends on several in vivo tests that determine its safety and potency. Assays for the determination of functionally active and/or immunoreactive toxin components and S-layer proteins have been developed and applied to the characterisation of anthrax vaccine. These technologies may support production of consistent and effective vaccines, and may ultimately reduce the requirements for in vivo testing.",

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T1 - Novel in vitro functional assays for the determination of anthrax toxin components.

AU - Hallis, B.

AU - Silman, Nigel

AU - Noonan, S.

AU - Baker, R.

AU - Roberts, A. D.

AU - Quinn, C. P.

AU - Marks, T.

AU - Wiblin, C.

AU - Lloyd, Graham

AU - Robinson, A.

AU - Hudson, Michael

N1 - Copyright: This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

PY - 2002

Y1 - 2002

N2 - The characterisation and evaluation of the UK licensed human anthrax vaccine depends on several in vivo tests that determine its safety and potency. Assays for the determination of functionally active and/or immunoreactive toxin components and S-layer proteins have been developed and applied to the characterisation of anthrax vaccine. These technologies may support production of consistent and effective vaccines, and may ultimately reduce the requirements for in vivo testing.

AB - The characterisation and evaluation of the UK licensed human anthrax vaccine depends on several in vivo tests that determine its safety and potency. Assays for the determination of functionally active and/or immunoreactive toxin components and S-layer proteins have been developed and applied to the characterisation of anthrax vaccine. These technologies may support production of consistent and effective vaccines, and may ultimately reduce the requirements for in vivo testing.

UR - https://www.scopus.com/pages/publications/0038645877

M3 - Article

C2 - 12678256

AN - SCOPUS:0038645877

SN - 1424-6074

VL - 111

SP - 321

EP - 326

JO - Developments in biologicals

JF - Developments in biologicals

ER -

Novel in vitro functional assays for the determination of anthrax toxin components.

Abstract

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