Novel in vitro functional assays for the determination of anthrax toxin components.

B. Hallis*, Nigel Silman, S. Noonan, R. Baker, A. D. Roberts, C. P. Quinn, T. Marks, C. Wiblin, Graham Lloyd, A. Robinson, Michael Hudson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The characterisation and evaluation of the UK licensed human anthrax vaccine depends on several in vivo tests that determine its safety and potency. Assays for the determination of functionally active and/or immunoreactive toxin components and S-layer proteins have been developed and applied to the characterisation of anthrax vaccine. These technologies may support production of consistent and effective vaccines, and may ultimately reduce the requirements for in vivo testing.

Original languageEnglish
Pages (from-to)321-326
Number of pages6
JournalDevelopments in biologicals
Volume111
Publication statusPublished - 2002

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