Nosocomial outbreak of drug-resistant streptococcus pneumoniae serotype 9V in an adult respiratory medicine ward

Elita Jauneikaite, Zareena Khan-Orakzai, Georgia Kapatai, Susannah Bloch, Julie Singleton, Sara Atkin, Victoria Shah, James Hatcher, Dunisha Samarasinghe, Carmen Sheppard, Norman Fry, Giovanni Satta, Shiranee Sriskandan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Streptococcus pneumoniae infections arising in hospitalized patients are often assumed to be sporadic and linked to community acquisition. Here, whole-genome sequencing was used to demonstrate nosocomial acquisition of antimicrobial-resistant sequence type 156 (ST156) serotype 9V S. pneumoniae in 3 respiratory patients that resulted in two bacteremias and one lower respiratory tract infection. Two of the cases arose in patients who had recently been discharged from the hospital and were readmitted from the community. Nosocomial spread was suspected solely because of the highly unusual resistance pattern and case presentations within 24 h of one another. The outbreak highlights the potential for rapid transmission and the short incubation period in the respiratory ward setting.

Original languageEnglish
Pages (from-to)776-782
Number of pages7
JournalJournal of Clinical Microbiology
Volume55
Issue number3
DOIs
Publication statusPublished - Mar 2017

Bibliographical note

Funding Information:
The research was partially funded by the Centre for Clinical Microbiology research budget, University College London, and the National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Healthcare Associated Infections and Antimicrobial Resistance at Imperial College London in partnership with Public Health England (PHE).

Publisher Copyright:
© Copyright 2017 American Society for Microbiology. All Rights Reserved.

Keywords

  • Bacteremia
  • Nosocomial infections
  • Pneumonia
  • Serotype 9V
  • Streptococcus pneumoniae

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