Norovirus gastroenteritis in a birth cohort in southern India

Vipin Kumar Menon, Santosh George, Rajiv Sarkar, Sidhartha Giri, Prasanna Samuel, Rosario Vivek, Anuradha Saravanabavan, Farzana Begum Liakath, Sasirekha Ramani, Miren Iturriza-Gomara, James J. Gray, David W. Brown, Mary K. Estes, Gagandeep Kang

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    Background Noroviruses are an important cause of gastroenteritis but little is known about disease and re-infection rates in community settings in Asia. Methods Disease, re-infection rates, strain prevalence and genetic susceptibility to noroviruses were investigated in a birth cohort of 373 Indian children followed up for three years. Stool samples from 1856 diarrheal episodes and 147 vomiting only episodes were screened for norovirus by RT-PCR. Norovirus positivity was correlated with clinical data, secretor status and ABO blood group. Results Of 1856 diarrheal episodes, 207 (11.2%) were associated with norovirus, of which 49(2.6%) were norovirus GI, 150(8.1%) norovirus GII, and 8 (0.4%) were mixed infections with both norovirus GI and GII. Of the 147 vomiting only episodes, 30 (20.4%) were positive for norovirus in stool, of which 7 (4.8%) were norovirus GI and 23 (15.6%) GII. At least a third of the children developed norovirus associated diarrhea, with the first episode at a median age of 5 and 8 months for norovirus GI and GII, respectively. Norovirus GI.3 and GII.4 were the predominant genotypes (40.3% and 53.0%) with strain diversity and change in the predominant sub-cluster over time observed among GII viruses. A second episode of norovirus gastroenteritis was documented in 44/174 (25.3%) ever-infected children. Children with the G428A homozygous mutation for inactivation of the FUT2 enzyme (se428 se428 )wereata significantly lower risk (48/190) of infection with norovirus (p = 0.01).

    Original languageEnglish
    Article numbere0157007
    JournalPLoS ONE
    Issue number6
    Publication statusPublished - Jun 2016

    Bibliographical note

    Publisher Copyright:
    © 2016 Menon et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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