Non-travel-associated hepatitis E in England and Wales: Demographic, clinical, and molecular epidemiological characteristics

Samreen Ijaz; Eve Arnold; Malcolm Banks; Richard P. Bendall; Matthew E. Cramp; Richard Cunningham; Harry R. Dalton; Tim J. Harrison; Simon F. Hill; Lorna MacFarlane; Rolf E. Meigh; Shuja Shafi; Martin J. Sheppard; Jacquie Smithson; Melanie P. Wilson; Chong Gee Teo

doi:10.1086/444396

Non-travel-associated hepatitis E in England and Wales: Demographic, clinical, and molecular epidemiological characteristics

Samreen Ijaz^*, Eve Arnold, Malcolm Banks, Richard P. Bendall, Matthew E. Cramp, Richard Cunningham, Harry R. Dalton, Tim J. Harrison, Simon F. Hill, Lorna MacFarlane, Rolf E. Meigh, Shuja Shafi, Martin J. Sheppard, Jacquie Smithson, Melanie P. Wilson, Chong Gee Teo

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Between 1996 and 2003, 186 cases of hepatitis E were serologically diagnosed. Of these, 17 (9%) were not associated with recent travel abroad. Patients were >55 years old (range, 56-82 years old) and tended to be male (76%). Two patients presented with fulminant hepatitis. A total of 129 (69%) cases were associated with recent travel to countries where hepatitis E virus (HEV) is hyperendemic. Compared with patients with travel-associated disease, patients with non-travel-associated disease were more likely to be older, living in coastal or estuarine areas, not of South Asian ethnicity, and infected by genotype 3 strains of HEV. The genotype 3 subgenomic nucleotide sequences were unique and closely related to those from British pigs. Patients infected by HEV indigenous to England and Wales tended to belong to a distinct demographic group, there were multiple sources of infection, and pigs might have been a viral reservoir.

Original language	English
Pages (from-to)	1166-1172
Number of pages	7
Journal	Journal of Infectious Diseases
Volume	192
Issue number	7
DOIs	https://doi.org/10.1086/444396
Publication status	Published - 1 Sep 2005

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Ijaz, S., Arnold, E., Banks, M., Bendall, R. P., Cramp, M. E., Cunningham, R., Dalton, H. R., Harrison, T. J., Hill, S. F., MacFarlane, L., Meigh, R. E., Shafi, S., Sheppard, M. J., Smithson, J., Wilson, M. P., & Teo, C. G. (2005). Non-travel-associated hepatitis E in England and Wales: Demographic, clinical, and molecular epidemiological characteristics. Journal of Infectious Diseases, 192(7), 1166-1172. https://doi.org/10.1086/444396

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title = "Non-travel-associated hepatitis E in England and Wales: Demographic, clinical, and molecular epidemiological characteristics",

abstract = "Between 1996 and 2003, 186 cases of hepatitis E were serologically diagnosed. Of these, 17 (9%) were not associated with recent travel abroad. Patients were >55 years old (range, 56-82 years old) and tended to be male (76%). Two patients presented with fulminant hepatitis. A total of 129 (69%) cases were associated with recent travel to countries where hepatitis E virus (HEV) is hyperendemic. Compared with patients with travel-associated disease, patients with non-travel-associated disease were more likely to be older, living in coastal or estuarine areas, not of South Asian ethnicity, and infected by genotype 3 strains of HEV. The genotype 3 subgenomic nucleotide sequences were unique and closely related to those from British pigs. Patients infected by HEV indigenous to England and Wales tended to belong to a distinct demographic group, there were multiple sources of infection, and pigs might have been a viral reservoir.",

author = "Samreen Ijaz and Eve Arnold and Malcolm Banks and Bendall, {Richard P.} and Cramp, {Matthew E.} and Richard Cunningham and Dalton, {Harry R.} and Harrison, {Tim J.} and Hill, {Simon F.} and Lorna MacFarlane and Meigh, {Rolf E.} and Shuja Shafi and Sheppard, {Martin J.} and Jacquie Smithson and Wilson, {Melanie P.} and Teo, {Chong Gee}",

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Ijaz, S, Arnold, E, Banks, M, Bendall, RP, Cramp, ME, Cunningham, R, Dalton, HR, Harrison, TJ, Hill, SF, MacFarlane, L, Meigh, RE, Shafi, S, Sheppard, MJ, Smithson, J, Wilson, MP & Teo, CG 2005, 'Non-travel-associated hepatitis E in England and Wales: Demographic, clinical, and molecular epidemiological characteristics', Journal of Infectious Diseases, vol. 192, no. 7, pp. 1166-1172. https://doi.org/10.1086/444396

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T1 - Non-travel-associated hepatitis E in England and Wales

T2 - Demographic, clinical, and molecular epidemiological characteristics

AU - Ijaz, Samreen

AU - Arnold, Eve

AU - Banks, Malcolm

AU - Bendall, Richard P.

AU - Cramp, Matthew E.

AU - Cunningham, Richard

AU - Dalton, Harry R.

AU - Harrison, Tim J.

AU - Hill, Simon F.

AU - MacFarlane, Lorna

AU - Meigh, Rolf E.

AU - Shafi, Shuja

AU - Sheppard, Martin J.

AU - Smithson, Jacquie

AU - Wilson, Melanie P.

AU - Teo, Chong Gee

PY - 2005/9/1

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N2 - Between 1996 and 2003, 186 cases of hepatitis E were serologically diagnosed. Of these, 17 (9%) were not associated with recent travel abroad. Patients were >55 years old (range, 56-82 years old) and tended to be male (76%). Two patients presented with fulminant hepatitis. A total of 129 (69%) cases were associated with recent travel to countries where hepatitis E virus (HEV) is hyperendemic. Compared with patients with travel-associated disease, patients with non-travel-associated disease were more likely to be older, living in coastal or estuarine areas, not of South Asian ethnicity, and infected by genotype 3 strains of HEV. The genotype 3 subgenomic nucleotide sequences were unique and closely related to those from British pigs. Patients infected by HEV indigenous to England and Wales tended to belong to a distinct demographic group, there were multiple sources of infection, and pigs might have been a viral reservoir.

AB - Between 1996 and 2003, 186 cases of hepatitis E were serologically diagnosed. Of these, 17 (9%) were not associated with recent travel abroad. Patients were >55 years old (range, 56-82 years old) and tended to be male (76%). Two patients presented with fulminant hepatitis. A total of 129 (69%) cases were associated with recent travel to countries where hepatitis E virus (HEV) is hyperendemic. Compared with patients with travel-associated disease, patients with non-travel-associated disease were more likely to be older, living in coastal or estuarine areas, not of South Asian ethnicity, and infected by genotype 3 strains of HEV. The genotype 3 subgenomic nucleotide sequences were unique and closely related to those from British pigs. Patients infected by HEV indigenous to England and Wales tended to belong to a distinct demographic group, there were multiple sources of infection, and pigs might have been a viral reservoir.

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Non-travel-associated hepatitis E in England and Wales: Demographic, clinical, and molecular epidemiological characteristics

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