TY - JOUR
T1 - Non-Hodgkin's Lymphoma, Leukemia, and Exposures in Agriculture
T2 - Results from the Italian Multicenter Case-Control Study
AU - Miligi, Lucia
AU - Costantini, Adele Seniori
AU - Bolejack, Vanessa
AU - Veraldi, Angela
AU - Benvenuti, Alessandra
AU - Nanni, Oriana
AU - Ramazzotti, Valerio
AU - Tumino, Rosario
AU - Stagnaro, Emanuele
AU - Rodella, Stefania
AU - Fontana, Arabella
AU - Vindigni, Carla
AU - Vineis, Paolo
PY - 2003/12
Y1 - 2003/12
N2 - Background: The etiology of non-Hodgkin's lymphoma (NHL) and leukemia is still largely unknown, but exposure to chemicals, in particular pesticides, has been suggested to be a risk factor. Methods: A large population-based case-control study was conducted in Italy with the aim of investigating the associations between pesticide exposure and NHL, and solvents and leukemia. Data presented in this article refer to 1,575 interviewed cases and 1,232 controls in the nine agricultural study areas. Results: Exposure to nitro-derivatives and phenylimides among fungicides, hydrocarbon derivatives and insecticide oils among insecticides, and the herbicide amides are the chemical classes observed to be associated with the pathologies under investigation. Conclusions: The results of the case-control study suggest an increased risk for NHL and leukemia, and some chemical classes of pesticides, although few are statistically significant and some are based on few exposed cases. The results also show that men and women experience both similar and different risks for the same environmental agricultural exposures.
AB - Background: The etiology of non-Hodgkin's lymphoma (NHL) and leukemia is still largely unknown, but exposure to chemicals, in particular pesticides, has been suggested to be a risk factor. Methods: A large population-based case-control study was conducted in Italy with the aim of investigating the associations between pesticide exposure and NHL, and solvents and leukemia. Data presented in this article refer to 1,575 interviewed cases and 1,232 controls in the nine agricultural study areas. Results: Exposure to nitro-derivatives and phenylimides among fungicides, hydrocarbon derivatives and insecticide oils among insecticides, and the herbicide amides are the chemical classes observed to be associated with the pathologies under investigation. Conclusions: The results of the case-control study suggest an increased risk for NHL and leukemia, and some chemical classes of pesticides, although few are statistically significant and some are based on few exposed cases. The results also show that men and women experience both similar and different risks for the same environmental agricultural exposures.
KW - Agriculture
KW - Crop
KW - Fungicides
KW - Gender
KW - Herbicides
KW - Insecticides
KW - Leukemia
KW - Non-Hodgkin's lymphoma
KW - Pesticide exposure assessment
UR - http://www.scopus.com/inward/record.url?scp=10744225131&partnerID=8YFLogxK
U2 - 10.1002/ajim.10289
DO - 10.1002/ajim.10289
M3 - Article
C2 - 14635239
AN - SCOPUS:10744225131
SN - 0271-3586
VL - 44
SP - 627
EP - 636
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
IS - 6
ER -