Non-A hepatitis B virus genotypes in antenatal clinics, United Kingdom

Samir Dervisevic*, Samreen Ijaz, Shahneila Chaudry, Richard S. Tedder

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

In the United Kingdom, the National Screening Programme for identification of hepatitits B virus (HBV) infection in pregnant women uses HBV e antigen (HBeAg) and antibody to HBeAg (anti-HBe) as markers of infectivity to determine use of immunoglobulin for hepatitis B. Serum samples from 114 HBV-infected women were analyzed. Viral loads correlated with HBeAg/anti-HBe status and viral genotypes. Among 95 mothers whose serum contained anti-HBe, viral loads ranged between undetectable and 8.6 × 106 IU/mL (median 228 IU/mL). Ten (10.5%) of these mothers had plasma viral loads >104 IU/mL; 6 were infected with genotype E and one each with genotypes A, B, C, and D. All viruses had precore stop codon or basal core promoter mutations. Preponderance of genotypes other than A among antenatal mothers in the United Kingdom reflects increasing globalization and trends in immigration. HBeAg serostatus is no longer sufficiently accurate for inferring potential infectivity of pregnant HBV carriers.

Original languageEnglish
Pages (from-to)1689-1693
Number of pages5
JournalEmerging Infectious Diseases
Volume13
Issue number11
DOIs
Publication statusPublished - Nov 2007

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