No evidence of transfusion transmission of Adenovirus and Epstein-Barr virus infections in paediatric recipients post-bone marrow transplant

P. Patel; P. Tuke; K. Tettmar; E. Cloutman-Green; J. Hartley; N. Klein; P. Veys; Richard Tedder

doi:10.1111/vox.12256

No evidence of transfusion transmission of Adenovirus and Epstein-Barr virus infections in paediatric recipients post-bone marrow transplant

P. Patel^*, P. Tuke, K. Tettmar, E. Cloutman-Green, J. Hartley, N. Klein, P. Veys, Richard Tedder

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Adenovirus and Epstein-Barr virus can cause significant morbidity and mortality in paediatric patients post-bone marrow transplant. The source of infection is thought to be either reactivation of latent viruses or primary infection. We have investigated whether transfusion of blood components from viraemic donors could provide a route of primary infection in these patients and sought the prevalence of viraemia in the blood donor population from England. In 32 linked donor/recipient samples and 300 unselected blood donors, we found no evidence to suggest that these infections in paediatric bone marrow transplant recipients had been acquired from transfused blood components.

Original language	English
Pages (from-to)	95-97
Number of pages	3
Journal	Vox Sanguinis
Volume	109
Issue number	1
DOIs	https://doi.org/10.1111/vox.12256
Publication status	Published - 1 Jul 2015

Bibliographical note

Publisher Copyright:
© 2015 International Society of Blood Transfusion.

Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.

Keywords

Blood safety
Bone marrow
Transfusion - paediatric
Transfusion - transmissible infections
Transplantation

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10.1111/vox.12256

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abstract = "Adenovirus and Epstein-Barr virus can cause significant morbidity and mortality in paediatric patients post-bone marrow transplant. The source of infection is thought to be either reactivation of latent viruses or primary infection. We have investigated whether transfusion of blood components from viraemic donors could provide a route of primary infection in these patients and sought the prevalence of viraemia in the blood donor population from England. In 32 linked donor/recipient samples and 300 unselected blood donors, we found no evidence to suggest that these infections in paediatric bone marrow transplant recipients had been acquired from transfused blood components.",

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AU - Patel, P.

AU - Tuke, P.

AU - Tettmar, K.

AU - Cloutman-Green, E.

AU - Hartley, J.

AU - Klein, N.

AU - Veys, P.

AU - Tedder, Richard

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N2 - Adenovirus and Epstein-Barr virus can cause significant morbidity and mortality in paediatric patients post-bone marrow transplant. The source of infection is thought to be either reactivation of latent viruses or primary infection. We have investigated whether transfusion of blood components from viraemic donors could provide a route of primary infection in these patients and sought the prevalence of viraemia in the blood donor population from England. In 32 linked donor/recipient samples and 300 unselected blood donors, we found no evidence to suggest that these infections in paediatric bone marrow transplant recipients had been acquired from transfused blood components.

AB - Adenovirus and Epstein-Barr virus can cause significant morbidity and mortality in paediatric patients post-bone marrow transplant. The source of infection is thought to be either reactivation of latent viruses or primary infection. We have investigated whether transfusion of blood components from viraemic donors could provide a route of primary infection in these patients and sought the prevalence of viraemia in the blood donor population from England. In 32 linked donor/recipient samples and 300 unselected blood donors, we found no evidence to suggest that these infections in paediatric bone marrow transplant recipients had been acquired from transfused blood components.

KW - Blood safety

KW - Bone marrow

KW - Transfusion - paediatric

KW - Transfusion - transmissible infections

KW - Transplantation

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No evidence of transfusion transmission of Adenovirus and Epstein-Barr virus infections in paediatric recipients post-bone marrow transplant

Abstract

Bibliographical note

Keywords

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