No effect of 2008/09 seasonal influenza vaccination on the risk of pandemic H1N1 2009 influenza infection in England

Richard Pebody; Nicholas Andrews; Pauline Waight; Rashmi Malkani; Christine McCartney; Joanna Ellis; Elizbeth Miller

doi:10.1016/j.vaccine.2011.01.046

No effect of 2008/09 seasonal influenza vaccination on the risk of pandemic H1N1 2009 influenza infection in England

Richard Pebody^*
, Nicholas Andrews
, Pauline Waight
, Rashmi Malkani
, Christine McCartney
, Joanna Ellis
, Elizbeth Miller

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

This study reports effectiveness of trivalent influenza vaccine (TIV) against confirmed pandemic influenza infection in England using a retrospective test-negative case-control study. Cases and controls were frequency matched by age, swabbing-week and region. On univariable and multivariable analysis adjusted for underlying clinical risk factors, cases were no more or less likely than controls to be vaccinated with 2008-09 or 2007-08 season TIV. Adjusted vaccine effectiveness for the former was -6% (-43% to 22%). Vaccine effectiveness did not differ significantly by age-group or hospitalisation status. There was no evidence prior vaccination with TIV significantly altered subsequent risk of pandemic influenza H1N1 2009 infection.

Original language	English
Pages (from-to)	2613-2618
Number of pages	6
Journal	Vaccine
Volume	29
Issue number	14
DOIs	https://doi.org/10.1016/j.vaccine.2011.01.046
Publication status	Published - 21 Mar 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Pandemic
TIV effectiveness

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10.1016/j.vaccine.2011.01.046

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title = "No effect of 2008/09 seasonal influenza vaccination on the risk of pandemic H1N1 2009 influenza infection in England",

abstract = "This study reports effectiveness of trivalent influenza vaccine (TIV) against confirmed pandemic influenza infection in England using a retrospective test-negative case-control study. Cases and controls were frequency matched by age, swabbing-week and region. On univariable and multivariable analysis adjusted for underlying clinical risk factors, cases were no more or less likely than controls to be vaccinated with 2008-09 or 2007-08 season TIV. Adjusted vaccine effectiveness for the former was -6\% (-43\% to 22\%). Vaccine effectiveness did not differ significantly by age-group or hospitalisation status. There was no evidence prior vaccination with TIV significantly altered subsequent risk of pandemic influenza H1N1 2009 infection.",

keywords = "Pandemic, TIV effectiveness",

author = "Richard Pebody and Nicholas Andrews and Pauline Waight and Rashmi Malkani and Christine McCartney and Joanna Ellis and Elizbeth Miller",

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doi = "10.1016/j.vaccine.2011.01.046",

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AU - Pebody, Richard

AU - Andrews, Nicholas

AU - Waight, Pauline

AU - Malkani, Rashmi

AU - McCartney, Christine

AU - Ellis, Joanna

AU - Miller, Elizbeth

PY - 2011/3/21

Y1 - 2011/3/21

N2 - This study reports effectiveness of trivalent influenza vaccine (TIV) against confirmed pandemic influenza infection in England using a retrospective test-negative case-control study. Cases and controls were frequency matched by age, swabbing-week and region. On univariable and multivariable analysis adjusted for underlying clinical risk factors, cases were no more or less likely than controls to be vaccinated with 2008-09 or 2007-08 season TIV. Adjusted vaccine effectiveness for the former was -6% (-43% to 22%). Vaccine effectiveness did not differ significantly by age-group or hospitalisation status. There was no evidence prior vaccination with TIV significantly altered subsequent risk of pandemic influenza H1N1 2009 infection.

AB - This study reports effectiveness of trivalent influenza vaccine (TIV) against confirmed pandemic influenza infection in England using a retrospective test-negative case-control study. Cases and controls were frequency matched by age, swabbing-week and region. On univariable and multivariable analysis adjusted for underlying clinical risk factors, cases were no more or less likely than controls to be vaccinated with 2008-09 or 2007-08 season TIV. Adjusted vaccine effectiveness for the former was -6% (-43% to 22%). Vaccine effectiveness did not differ significantly by age-group or hospitalisation status. There was no evidence prior vaccination with TIV significantly altered subsequent risk of pandemic influenza H1N1 2009 infection.

KW - Pandemic

KW - TIV effectiveness

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M3 - Article

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AN - SCOPUS:79952222329

SN - 0264-410X

VL - 29

SP - 2613

EP - 2618

JO - Vaccine

JF - Vaccine

IS - 14

ER -

No effect of 2008/09 seasonal influenza vaccination on the risk of pandemic H1N1 2009 influenza infection in England

Abstract

UN SDGs

Keywords

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