TY - JOUR
T1 - New measles virus genotype associated with outbreak, China
AU - Zhang, Yan
AU - Ding, Zhengrong
AU - Wang, Huiling
AU - Li, Liqun
AU - Pang, Yankun
AU - Brown, Kevin
AU - Xu, Songtao
AU - Zhu, Zhen
AU - Rota, Paul A.
AU - Featherstone, David
AU - Xu, Wenbo
PY - 2010/6
Y1 - 2010/6
N2 - To determine the origin of the virus associated with a measles outbreak in Menglian County, Yunnan Province, People's Republic of China, in 2009, we conducted genetic analyses. Phylogenetic analyses based on nucleoprotein (N) and hemagglutinin (H) gene sequences showed that these Menglian viruses were not closely related to sequences of any World Health Organization (WHO) reference strains representing the 23 currently recognized genotypes. The minimum nucleotide divergence between the Menglian viruses and the most closely related reference strain, genotype D7, was 3.3% for the N gene and 3.0% for the H gene. A search of the databases of GenBank, WHO, and the Health Protection Agency Measles Nucleotide Surveillance showed that the Menglian viruses, together with the 2 older non-Menglian viruses, could be members of a new proposed measles genotype, d11. The new genotype designation will allow for better description of measles transmission patterns, especially in the Southeast Asian and Western Pacific regions.
AB - To determine the origin of the virus associated with a measles outbreak in Menglian County, Yunnan Province, People's Republic of China, in 2009, we conducted genetic analyses. Phylogenetic analyses based on nucleoprotein (N) and hemagglutinin (H) gene sequences showed that these Menglian viruses were not closely related to sequences of any World Health Organization (WHO) reference strains representing the 23 currently recognized genotypes. The minimum nucleotide divergence between the Menglian viruses and the most closely related reference strain, genotype D7, was 3.3% for the N gene and 3.0% for the H gene. A search of the databases of GenBank, WHO, and the Health Protection Agency Measles Nucleotide Surveillance showed that the Menglian viruses, together with the 2 older non-Menglian viruses, could be members of a new proposed measles genotype, d11. The new genotype designation will allow for better description of measles transmission patterns, especially in the Southeast Asian and Western Pacific regions.
UR - http://www.scopus.com/inward/record.url?scp=77952683194&partnerID=8YFLogxK
U2 - 10.3201/eid1606.100089
DO - 10.3201/eid1606.100089
M3 - Article
C2 - 20507744
AN - SCOPUS:77952683194
VL - 16
SP - 943
EP - 947
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
SN - 1080-6040
IS - 6
ER -
