Neutral gadolinium(III) complexes of bulky octadentate dtpa derivatives as potential contrast agents for magnetic resonance imaging

S. W. Annie Bligh; Anwar H.M.S. Chowdhury; Mary McPartlin; Ian J. Scowen; Robert Bulman

doi:10.1016/0277-5387(94)00318-9

Neutral gadolinium(III) complexes of bulky octadentate dtpa derivatives as potential contrast agents for magnetic resonance imaging

S. W. Annie Bligh^*
, Anwar H.M.S. Chowdhury
, Mary McPartlin
, Ian J. Scowen
, Robert Bulman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

A series of bulky and neutral gadolinium complexes of [bis(R-amide)dtpaH₃] (where R = Prⁱ,, Buⁱ,, Bz and phenylethyl, L¹--L⁴)) with potential application as contrast agents for magnetic resonance imaging has been prepared and characterized ; the relaxivity of these complexes is comparable to the contrast agent [Gd(dtpa)(H₂OO)]^; which is which is currently used in clinics; the X-ray structure analysis of the gadolinium(III) complex of L³ reveals a neutral nine-coordinate complex featuring a water molecule in the tricapped trigonal prismatic metal coordination sphere.

Original language	English
Pages (from-to)	567-569
Number of pages	3
Journal	Polyhedron
Volume	14
Issue number	4
DOIs	https://doi.org/10.1016/0277-5387(94)00318-9
Publication status	Published - Feb 1995

Bibliographical note

Funding Information:
Acknowleulyc~ments-We thank the S.E.R.C. for financial support (I.J.S.) and access to the Chemical Database Service at Daresbury. and Dr Orla Ni Dhubhghaill (Insti-tut de Chimie Minerale et Analytique. Lausanne) for the relaxivity measurements.

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@article{d3e96eb03fa9407a85d9caa74c274034,

title = "Neutral gadolinium(III) complexes of bulky octadentate dtpa derivatives as potential contrast agents for magnetic resonance imaging",

abstract = "A series of bulky and neutral gadolinium complexes of [bis(R-amide)dtpaH3] (where R = Pri,, Bui,, Bz and phenylethyl, L1--L4)) with potential application as contrast agents for magnetic resonance imaging has been prepared and characterized ; the relaxivity of these complexes is comparable to the contrast agent [Gd(dtpa)(H2OO)]; which is which is currently used in clinics; the X-ray structure analysis of the gadolinium(III) complex of L3 reveals a neutral nine-coordinate complex featuring a water molecule in the tricapped trigonal prismatic metal coordination sphere.",

author = "\{Annie Bligh\}, \{S. W.\} and Chowdhury, \{Anwar H.M.S.\} and Mary McPartlin and Scowen, \{Ian J.\} and Robert Bulman",

note = "Funding Information: Acknowleulyc\textasciitilde{}ments-We thank the S.E.R.C. for financial support (I.J.S.) and access to the Chemical Database Service at Daresbury. and Dr Orla Ni Dhubhghaill (Insti-tut de Chimie Minerale et Analytique. Lausanne) for the relaxivity measurements.",

year = "1995",

month = feb,

doi = "10.1016/0277-5387(94)00318-9",

language = "English",

volume = "14",

pages = "567--569",

journal = "Polyhedron",

issn = "0277-5387",

publisher = "Elsevier Ltd.",

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TY - JOUR

T1 - Neutral gadolinium(III) complexes of bulky octadentate dtpa derivatives as potential contrast agents for magnetic resonance imaging

AU - Annie Bligh, S. W.

AU - Chowdhury, Anwar H.M.S.

AU - McPartlin, Mary

AU - Scowen, Ian J.

AU - Bulman, Robert

N1 - Funding Information: Acknowleulyc~ments-We thank the S.E.R.C. for financial support (I.J.S.) and access to the Chemical Database Service at Daresbury. and Dr Orla Ni Dhubhghaill (Insti-tut de Chimie Minerale et Analytique. Lausanne) for the relaxivity measurements.

PY - 1995/2

Y1 - 1995/2

N2 - A series of bulky and neutral gadolinium complexes of [bis(R-amide)dtpaH3] (where R = Pri,, Bui,, Bz and phenylethyl, L1--L4)) with potential application as contrast agents for magnetic resonance imaging has been prepared and characterized ; the relaxivity of these complexes is comparable to the contrast agent [Gd(dtpa)(H2OO)]; which is which is currently used in clinics; the X-ray structure analysis of the gadolinium(III) complex of L3 reveals a neutral nine-coordinate complex featuring a water molecule in the tricapped trigonal prismatic metal coordination sphere.

AB - A series of bulky and neutral gadolinium complexes of [bis(R-amide)dtpaH3] (where R = Pri,, Bui,, Bz and phenylethyl, L1--L4)) with potential application as contrast agents for magnetic resonance imaging has been prepared and characterized ; the relaxivity of these complexes is comparable to the contrast agent [Gd(dtpa)(H2OO)]; which is which is currently used in clinics; the X-ray structure analysis of the gadolinium(III) complex of L3 reveals a neutral nine-coordinate complex featuring a water molecule in the tricapped trigonal prismatic metal coordination sphere.

UR - https://www.scopus.com/pages/publications/58149364043

U2 - 10.1016/0277-5387(94)00318-9

DO - 10.1016/0277-5387(94)00318-9

M3 - Article

AN - SCOPUS:58149364043

SN - 0277-5387

VL - 14

SP - 567

EP - 569

JO - Polyhedron

JF - Polyhedron

IS - 4

ER -

Neutral gadolinium(III) complexes of bulky octadentate dtpa derivatives as potential contrast agents for magnetic resonance imaging

Abstract

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