Nephrotic syndrome in infants and toddlers before and after introduction of the meningococcal B vaccine programme in England: An ecological study

Nicholas Andrews*, Julia Stowe, Elizabeth Miller

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

A possible increased risk of nephrotic syndrome (NS) following a meningococal group B vaccination campaign was identified during active safety surveillance in a province in Quebec, Canada where 4 cases were reported from an exposed population of ~490,000, a higher rate than in provinces not using the vaccine. Meningococcal B vaccine has been given routinely at 2, 4 and 12 months of age in the United Kingdom since September 2015. To investigate the Canadian signal we used English hospital admissions data from 2005 to 2019 in 2–23 month old children to determine whether the rate of NS changed following the introduction of the vaccine. The analysis was stratified by age 2–5 months, 6–11 months, 12–17 months and 18–23 months. The results showed no evidence of an increased risk with incidence rate ratios between 0.81 (95% confidence interval 0.56–1.19) for age 6–11 months and 1.18 (0.84–1.66) for age 12–17 months.

Original languageEnglish
Pages (from-to)4816-4819
Number of pages4
JournalVaccine
Volume38
Issue number31
DOIs
Publication statusPublished - 26 Jun 2020

Bibliographical note

Publisher Copyright:
© 2020

Keywords

  • Ecological
  • Meningococcal B vaccine
  • Nephrotic syndrome
  • Vaccine safety

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