Neonatal infection with G10P[11] rotavirus did not confer protection against subsequent rotavirus infection in a community cohort in Vellore, South India

Indrani Banerjee, Beryl Primrose Gladstone, Andrea M. Le Fevre, Sasirekha Ramani, Miren Iturriza-Gomara, James J. Gray, David W. Brown, Mary K. Estes, Jaya Prakash Muliyil, Shabbar Jaffar, Gagandeep Kang*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    40 Citations (Scopus)

    Abstract

    Background. Various observational studies have suggested that neonatal rotavirus infection confers protection against diarrhea due to subsequent rotavirus infection. We examined the incidence of rotavirus infection and diarrhea during the first 2 years of life among children infected with the G10P[11] rotavirus strain during the neonatal period and those not infected with rotavirus. Methods. Children were recruited at birth and were followed up at least twice weekly. Stool samples, collected every 2 weeks for surveillance and at each episode of diarrhea, were screened by enzyme-linked immunosorbent assay and were genotyped by polymerase chain reaction. Results. Among 33 children infected neonatally with G10P[11] and 300 children not infected with rotavirus, there was no significant difference in the rates of rotavirus-positive diarrhea (rate ratio [RR], 1.05 [95% confidence interval {CI}, 0.61-1.79]), moderate or severe rotavirus-positive diarrhea (RR, 1.42 [95% CI, 0.73-2.78]), or asymptomatic rotavirus shedding (RR, 1.25 [95% CI, 0.85-1.83]). Conclusion. Neonatal G10P[11] infection with a strain resembling a vaccine candidate did not confer protection against subsequent rotavirus infection or diarrhea of any severity in this setting.

    Original languageEnglish
    Pages (from-to)625-632
    Number of pages8
    JournalJournal of Infectious Diseases
    Volume195
    Issue number5
    DOIs
    Publication statusPublished - 1 Mar 2007

    Bibliographical note

    Funding Information:
    Received 5 May 2006; accepted 1 August 2006; electronically published 22 January 2007. Potential conflicts of interest: none reported. Financial support: Wellcome Trust Trilateral Cooperative Initiative on Infectious Diseases (grant 063144). a I.B. and B.P.G. contributed equally to the article. Reprints or correspondence: Dr. Gagandeep Kang, Dept. of Gastrointestinal Sciences, Christian Medical College, Vellore 632 004, India (gkang@cmcvellore .ac.in).

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