Abstract
Background. Various observational studies have suggested that neonatal rotavirus infection confers protection against diarrhea due to subsequent rotavirus infection. We examined the incidence of rotavirus infection and diarrhea during the first 2 years of life among children infected with the G10P[11] rotavirus strain during the neonatal period and those not infected with rotavirus. Methods. Children were recruited at birth and were followed up at least twice weekly. Stool samples, collected every 2 weeks for surveillance and at each episode of diarrhea, were screened by enzyme-linked immunosorbent assay and were genotyped by polymerase chain reaction. Results. Among 33 children infected neonatally with G10P[11] and 300 children not infected with rotavirus, there was no significant difference in the rates of rotavirus-positive diarrhea (rate ratio [RR], 1.05 [95% confidence interval {CI}, 0.61-1.79]), moderate or severe rotavirus-positive diarrhea (RR, 1.42 [95% CI, 0.73-2.78]), or asymptomatic rotavirus shedding (RR, 1.25 [95% CI, 0.85-1.83]). Conclusion. Neonatal G10P[11] infection with a strain resembling a vaccine candidate did not confer protection against subsequent rotavirus infection or diarrhea of any severity in this setting.
Original language | English |
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Pages (from-to) | 625-632 |
Number of pages | 8 |
Journal | Journal of Infectious Diseases |
Volume | 195 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1 Mar 2007 |
Bibliographical note
Funding Information:Received 5 May 2006; accepted 1 August 2006; electronically published 22 January 2007. Potential conflicts of interest: none reported. Financial support: Wellcome Trust Trilateral Cooperative Initiative on Infectious Diseases (grant 063144). a I.B. and B.P.G. contributed equally to the article. Reprints or correspondence: Dr. Gagandeep Kang, Dept. of Gastrointestinal Sciences, Christian Medical College, Vellore 632 004, India (gkang@cmcvellore .ac.in).