TY - JOUR
T1 - Naturally occurring major and minor capsid protein variants of human papillomavirus 45 (HPV45)
T2 - Differential recognition by cross-neutralizing antibodies generated by HPV vaccines
AU - Godi, Anna
AU - Facchetti, Alessandra
AU - Bissett, Sara L.
AU - Cocuzza, Clementina
AU - Miller, Elizabeth
AU - Beddows, Simon
N1 - Publisher Copyright:
© 2016, American Society for Microbiology.
PY - 2016
Y1 - 2016
N2 - We investigated naturally occurring variation within the major (L1) and minor (L2) capsid proteins of human papillomavirus genotype 45 (HPV45). Pseudoviruses (PsVs) representing HPV45 sublineages A1, A2, A3, B1, and B2 exhibited comparable particle- to-infectivity ratios and morphologies but demonstrated both increased (A2, A3, and B1) and decreased (B2) sensitivities to cross-neutralization by HPV vaccine antibodies compared to that of the A1 sublineage. Mutant PsVs identified HI loop residue 357 as being critical for conferring this differential sensitivity.
AB - We investigated naturally occurring variation within the major (L1) and minor (L2) capsid proteins of human papillomavirus genotype 45 (HPV45). Pseudoviruses (PsVs) representing HPV45 sublineages A1, A2, A3, B1, and B2 exhibited comparable particle- to-infectivity ratios and morphologies but demonstrated both increased (A2, A3, and B1) and decreased (B2) sensitivities to cross-neutralization by HPV vaccine antibodies compared to that of the A1 sublineage. Mutant PsVs identified HI loop residue 357 as being critical for conferring this differential sensitivity.
UR - http://www.scopus.com/inward/record.url?scp=84961159157&partnerID=8YFLogxK
U2 - 10.1128/JVI.02859-15
DO - 10.1128/JVI.02859-15
M3 - Article
C2 - 26719255
AN - SCOPUS:84961159157
SN - 0022-538X
VL - 90
SP - 3247
EP - 3252
JO - Journal of Virology
JF - Journal of Virology
IS - 6
ER -
