Naturally occurring capsid protein variants of human papillomavirus genotype 31 represent a single L1 serotype

Sara L. Bissett, Anna Godi, Maxime J.J. Fleury, Antoine Touze, Clementina Cocuzza, Simon Beddows*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

We investigated naturally occurring variation within the major (L1) and minor (L2) capsid proteins of oncogenic human papillomavirus (HPV) genotype 31 (HPV31) to determine the impact on capsid antigenicity. L1L2 pseudoviruses (PsVs) representing the three HPV31 variant lineages, variant lineages A, B, and C, exhibited comparable particle-to-infectivity ratios and morphologies. Lineage-specific L1L2 PsVs demonstrated subtle differences in susceptibility to neutralization by antibodies elicited following vaccination or preclinical L1 virus-like particle (VLP) immunization or by monoclonal antibodies; however, these differences were generally of a low magnitude. These data indicate that the diagnostic lineage-specific single nucleotide polymorphisms within the HPV31 capsid genes have a limited effect on L1 antibody-mediated neutralization and that the three HPV31 variant lineages belong to a single L1 serotype. These data contribute to our understanding of HPV L1 variant antigenicity.

Original languageEnglish
Pages (from-to)7748-7757
Number of pages10
JournalJournal of Virology
Volume89
Issue number15
DOIs
Publication statusPublished - 2015

Bibliographical note

Publisher Copyright:
© 2015, American Society for Microbiology.

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