Murine Radiation Myeloid Leukaemogenesis: A Possible Role for Radiation‐Sensitive Sites on Chromosome 2

George Breckon, David Papworth, Roger Cox*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    46 Citations (Scopus)

    Abstract

    There is a paucity of informative data on the potentially important role of specific sites of chromosomal instability in oncogenic processes. Chromosome 2 deletions and rearrangements are known to characterise radiation‐induced acute myeloid leukae mia in the mouse. Here we statistically establish a concordance between chromosome 2 breakpoint clusters in these leukaemias and chromosome 2 rearrangements carried at a high in vivo frequency by progeny of irradiated haemopoietic cells. Mechanisms of radiation myeloid leukaemogenesis are discussed with respect to multiple radiation‐sensitive sites encoded on chromosome 2 and the possible influence of genomic imprinting on inductive processes.

    Original languageEnglish
    Pages (from-to)367-375
    Number of pages9
    JournalGenes Chromosomes and Cancer
    Volume3
    Issue number5
    DOIs
    Publication statusPublished - Sept 1991

    Bibliographical note

    Copyright:
    Copyright 2016 Elsevier B.V., All rights reserved.

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