Multiple-drug-resistant tuberculosis

Francis Drobniewski*, D. C.S. Hutchison

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    5 Citations (Scopus)


    Multiple-drug-resistant tuberculosis (MDR-TB) is a serious global clinical, microbiological and public health problem. The World Health Organization-International Union Against Tuberculosis and Lung Disease Programme on Drug Resistance has reported data from 35 countries demonstrating that MDR-TB is widespread. One-third of countries had levels above 2% in new patients. Drug resistance, including MDR-TB, is caused by non-adherence to therapy, inappropriate treatment regimens, drug malabsorption and poor health infrastructure needed for the effective delivery of treatment. Individual risk factors for MDR-TB include prior TB therapy and human immunodeficiency virus infection. The key elements of a successful TB programme are the early detection of cases, particularly the most infectious and those infected with drug-resistant strains, combined with successful treatment using standardized regimens. Countries with poor TB control programmes have a higher prevalence of MDR-TB: a successful programme limits MDR-TB prevalence. MDR-TB treatment requires individualized therapy based on in vitro drug susceptibility testing.

    Original languageEnglish
    Pages (from-to)243-268
    Number of pages26
    JournalBailliere's Clinical Infectious Diseases
    Issue number2
    Publication statusPublished - 1999

    Bibliographical note

    Funding Information:
    This work was supported by Grant No. KO7 HL 3057–03 from the National Institutes of Health, and Grant No. PO HC96000892 from the Centers for Disease Control and Prevention.

    Copyright 2004 Elsevier Science B.V., Amsterdam. All rights reserved.


    • Directly observed therapy
    • Human immunodeficiency virus
    • Multiple-drug-resistant tuberculosis


    Dive into the research topics of 'Multiple-drug-resistant tuberculosis'. Together they form a unique fingerprint.

    Cite this