Multigene p-value integration based on SNPs investigation for seeking radiosensitivity signatures

Joanna Zyla*, Christophe Badie, Ghazi Alsbeih, Joanna Polanska

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Dysregulation of apoptosis is a key attribute of cancer, especially the one induced by p53 expression disruption. Radiotherapy, sometimes supported by chemotherapy and/or pre-surgery, is recommended in majority of cases, but despite of the very well defined treatment protocols and high quality irradiation procedure, the huge dispersion in response to the radiotherapy is observed among cancer patients. Patient radiosensitivity, according to up-to-date knowledge, is at least partially responsible for different reactions to ionising radiation. Here we concentrate on investigation of single nucleotide polymorphisms (SNP) which can possibly explain the radiation response phenomena. To reach this goal dependent and independent methods of p-value integrations are presented and compared. Both statistical and molecular function domains are used in comparison study. We propose a novel method of p-value integration which includes the control of gene expression trend and introduces the adaptive significance level. What is more the multigene approach is proposed in contrary to classical single gene investigation. As a result, set of statistically significant polymorphisms was obtained, among which some were identified as possible deleterious for KRAS signalling pathway.

Original languageEnglish
Title of host publicationBioinformatics and Biomedical Engineering - 4th International Conference, IWBBIO 2016, Proceedings
EditorsFrancisco Ortuno, Ignacio Rojas
PublisherSpringer Verlag
Pages125-134
Number of pages10
ISBN (Print)9783319317434
DOIs
Publication statusPublished - 2016
Event4th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2016 - Granada, Spain
Duration: 20 Apr 201622 Apr 2016

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume9656
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference4th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2016
Country/TerritorySpain
CityGranada
Period20/04/1622/04/16

Bibliographical note

Publisher Copyright:
© Springer International Publishing Switzerland 2016.

Keywords

  • P-value integration
  • Radiosensitivity
  • Single nucleotide polymorphism

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