Multidrug-resistant tuberculosis in europe, 2010-2011

Gunar Günther; Frank Van Leth; Sofa Alexandru; Neus Altet; Korkut Avsar; Didi Bang; Raisa Barbuta; Graham Bothamley; Ana Ciobanu; Valeriu Crudu; Manfred Danilovits; Martin Dedicoat; Raquel Duarte; Gina Gualano; Heinke Kunst; Wiel De Lange; Vaira Leimane; Cecile Magis-Escurra; Anne Marie McLaughlin; Inge Muylle; Veronika Polcová; Emanuele Pontali; Christina Popa; Rudolf Rumetshofer; Alena Skrahina; Varvara Solodovnikova; Victor Spinu; Simon Tiberi; Piret Viiklepp; Christoph Lange; Marcel Rowhani; Vera Avchinko; Dzimitry Katovich; Dzimitri Klimuk; Valentina Lobik; Zoya Rohaya; Alexander Shirochyn; Jana Kotrbova; Martina Vasakova; Aase Bengard Andersen; Nelleke Smitsman; Ralf Mütterlein; Saverio De Lorenzo; Liga Rusmane; Ana Donica; Ilie Cernenco; Vera Dubceac; Femke Cuppen; Inge De Guchtenaire; Robert Meesters; Mark Te Pas; Bram Prins; Ana Atunes; Dan Gainaru; Elmira Ibraim; Mirela Tigau; Juan Cayla; Laia Fina; Maria Luiza De Souza Galvao; José Maldonado

doi:10.3201/eid2103.141343

Multidrug-resistant tuberculosis in europe, 2010-2011

Gunar Günther, Frank Van Leth, Sofa Alexandru, Neus Altet, Korkut Avsar, Didi Bang, Raisa Barbuta, Graham Bothamley, Ana Ciobanu, Valeriu Crudu, Manfred Danilovits, Martin Dedicoat, Raquel Duarte, Gina Gualano, Heinke Kunst, Wiel De Lange, Vaira Leimane, Cecile Magis-Escurra, Anne Marie McLaughlin, Inge MuylleVeronika Polcová, Emanuele Pontali, Christina Popa, Rudolf Rumetshofer, Alena Skrahina, Varvara Solodovnikova, Victor Spinu, Simon Tiberi, Piret Viiklepp, Christoph Lange^*, Marcel Rowhani, Vera Avchinko, Dzimitry Katovich, Dzimitri Klimuk, Valentina Lobik, Zoya Rohaya, Alexander Shirochyn, Jana Kotrbova, Martina Vasakova, Aase Bengard Andersen, Nelleke Smitsman, Ralf Mütterlein, Saverio De Lorenzo, Liga Rusmane, Ana Donica, Ilie Cernenco, Vera Dubceac, Femke Cuppen, Inge De Guchtenaire, Robert Meesters, Mark Te Pas, Bram Prins, Ana Atunes, Dan Gainaru, Elmira Ibraim, Mirela Tigau, Juan Cayla, Laia Fina, Maria Luiza De Souza Galvao, José Maldonado

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

84 Citations (Scopus)

Abstract

Drug-resistant Mycobacterium tuberculosis is challenging elimination of tuberculosis (TB). We evaluated risk factors for TB and levels of second-line drug resistance in M. tuberculosis in patients in Europe with multidrug-resistant (MDR) TB. A total of 380 patients with MDR TB and 376 patients with non-MDR TB were enrolled at 23 centers in 16 countries in Europe during 2010-2011. A total of 52.4% of MDR TB patients had never been treated for TB, which suggests primary transmission of MDR M. tuberculosis. At initiation of treatment for MDR TB, 59.7% of M. tuberculosis strains tested were resistant to pyrazinamide, 51.1% were resistant to >1 second-line drug, 26.6% were resistant to second-line injectable drugs, 17.6% were resistant to fuoroquinolones, and 6.8% were extensively drug resistant. Previous treatment for TB was the strongest risk factor for MDR TB. High levels of primary transmission and advanced resistance to second-line drugs characterize MDR TB cases in Europe.

Original language	English
Pages (from-to)	409-416
Number of pages	8
Journal	Emerging Infectious Diseases
Volume	21
Issue number	3
DOIs	https://doi.org/10.3201/eid2103.141343
Publication status	Published - 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015, Centers for Disease Control and Prevention (CDC). All rights reserved.

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10.3201/eid2103.141343

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Günther, G., Van Leth, F., Alexandru, S., Altet, N., Avsar, K., Bang, D., Barbuta, R., Bothamley, G., Ciobanu, A., Crudu, V., Danilovits, M., Dedicoat, M., Duarte, R., Gualano, G., Kunst, H., De Lange, W., Leimane, V., Magis-Escurra, C., McLaughlin, A. M., ... Maldonado, J. (2015). Multidrug-resistant tuberculosis in europe, 2010-2011. Emerging Infectious Diseases, 21(3), 409-416. https://doi.org/10.3201/eid2103.141343

@article{71f9b8a8f78e4064b9d052b48a43efd4,

title = "Multidrug-resistant tuberculosis in europe, 2010-2011",

abstract = "Drug-resistant Mycobacterium tuberculosis is challenging elimination of tuberculosis (TB). We evaluated risk factors for TB and levels of second-line drug resistance in M. tuberculosis in patients in Europe with multidrug-resistant (MDR) TB. A total of 380 patients with MDR TB and 376 patients with non-MDR TB were enrolled at 23 centers in 16 countries in Europe during 2010-2011. A total of 52.4\% of MDR TB patients had never been treated for TB, which suggests primary transmission of MDR M. tuberculosis. At initiation of treatment for MDR TB, 59.7\% of M. tuberculosis strains tested were resistant to pyrazinamide, 51.1\% were resistant to >1 second-line drug, 26.6\% were resistant to second-line injectable drugs, 17.6\% were resistant to fuoroquinolones, and 6.8\% were extensively drug resistant. Previous treatment for TB was the strongest risk factor for MDR TB. High levels of primary transmission and advanced resistance to second-line drugs characterize MDR TB cases in Europe.",

author = "Gunar G{\"u}nther and \{Van Leth\}, Frank and Sofa Alexandru and Neus Altet and Korkut Avsar and Didi Bang and Raisa Barbuta and Graham Bothamley and Ana Ciobanu and Valeriu Crudu and Manfred Danilovits and Martin Dedicoat and Raquel Duarte and Gina Gualano and Heinke Kunst and \{De Lange\}, Wiel and Vaira Leimane and Cecile Magis-Escurra and McLaughlin, \{Anne Marie\} and Inge Muylle and Veronika Polcov{\'a} and Emanuele Pontali and Christina Popa and Rudolf Rumetshofer and Alena Skrahina and Varvara Solodovnikova and Victor Spinu and Simon Tiberi and Piret Viiklepp and Christoph Lange and Marcel Rowhani and Vera Avchinko and Dzimitry Katovich and Dzimitri Klimuk and Valentina Lobik and Zoya Rohaya and Alexander Shirochyn and Jana Kotrbova and Martina Vasakova and Andersen, \{Aase Bengard\} and Nelleke Smitsman and Ralf M{\"u}tterlein and \{De Lorenzo\}, Saverio and Liga Rusmane and Ana Donica and Ilie Cernenco and Vera Dubceac and Femke Cuppen and \{De Guchtenaire\}, Inge and Robert Meesters and \{Te Pas\}, Mark and Bram Prins and Ana Atunes and Dan Gainaru and Elmira Ibraim and Mirela Tigau and Juan Cayla and Laia Fina and \{De Souza Galvao\}, \{Maria Luiza\} and Jos{\'e} Maldonado",

year = "2015",

doi = "10.3201/eid2103.141343",

language = "English",

volume = "21",

pages = "409--416",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

number = "3",

}

Günther, G, Van Leth, F, Alexandru, S, Altet, N, Avsar, K, Bang, D, Barbuta, R, Bothamley, G, Ciobanu, A, Crudu, V, Danilovits, M, Dedicoat, M, Duarte, R, Gualano, G, Kunst, H, De Lange, W, Leimane, V, Magis-Escurra, C, McLaughlin, AM, Muylle, I, Polcová, V, Pontali, E, Popa, C, Rumetshofer, R, Skrahina, A, Solodovnikova, V, Spinu, V, Tiberi, S, Viiklepp, P, Lange, C, Rowhani, M, Avchinko, V, Katovich, D, Klimuk, D, Lobik, V, Rohaya, Z, Shirochyn, A, Kotrbova, J, Vasakova, M, Andersen, AB, Smitsman, N, Mütterlein, R, De Lorenzo, S, Rusmane, L, Donica, A, Cernenco, I, Dubceac, V, Cuppen, F, De Guchtenaire, I, Meesters, R, Te Pas, M, Prins, B, Atunes, A, Gainaru, D, Ibraim, E, Tigau, M, Cayla, J, Fina, L, De Souza Galvao, ML & Maldonado, J 2015, 'Multidrug-resistant tuberculosis in europe, 2010-2011', Emerging Infectious Diseases, vol. 21, no. 3, pp. 409-416. https://doi.org/10.3201/eid2103.141343

TY - JOUR

T1 - Multidrug-resistant tuberculosis in europe, 2010-2011

AU - Günther, Gunar

AU - Van Leth, Frank

AU - Alexandru, Sofa

AU - Altet, Neus

AU - Avsar, Korkut

AU - Bang, Didi

AU - Barbuta, Raisa

AU - Bothamley, Graham

AU - Ciobanu, Ana

AU - Crudu, Valeriu

AU - Danilovits, Manfred

AU - Dedicoat, Martin

AU - Duarte, Raquel

AU - Gualano, Gina

AU - Kunst, Heinke

AU - De Lange, Wiel

AU - Leimane, Vaira

AU - Magis-Escurra, Cecile

AU - McLaughlin, Anne Marie

AU - Muylle, Inge

AU - Polcová, Veronika

AU - Pontali, Emanuele

AU - Popa, Christina

AU - Rumetshofer, Rudolf

AU - Skrahina, Alena

AU - Solodovnikova, Varvara

AU - Spinu, Victor

AU - Tiberi, Simon

AU - Viiklepp, Piret

AU - Lange, Christoph

AU - Rowhani, Marcel

AU - Avchinko, Vera

AU - Katovich, Dzimitry

AU - Klimuk, Dzimitri

AU - Lobik, Valentina

AU - Rohaya, Zoya

AU - Shirochyn, Alexander

AU - Kotrbova, Jana

AU - Vasakova, Martina

AU - Andersen, Aase Bengard

AU - Smitsman, Nelleke

AU - Mütterlein, Ralf

AU - De Lorenzo, Saverio

AU - Rusmane, Liga

AU - Donica, Ana

AU - Cernenco, Ilie

AU - Dubceac, Vera

AU - Cuppen, Femke

AU - De Guchtenaire, Inge

AU - Meesters, Robert

AU - Te Pas, Mark

AU - Prins, Bram

AU - Atunes, Ana

AU - Gainaru, Dan

AU - Ibraim, Elmira

AU - Tigau, Mirela

AU - Cayla, Juan

AU - Fina, Laia

AU - De Souza Galvao, Maria Luiza

AU - Maldonado, José

PY - 2015

Y1 - 2015

N2 - Drug-resistant Mycobacterium tuberculosis is challenging elimination of tuberculosis (TB). We evaluated risk factors for TB and levels of second-line drug resistance in M. tuberculosis in patients in Europe with multidrug-resistant (MDR) TB. A total of 380 patients with MDR TB and 376 patients with non-MDR TB were enrolled at 23 centers in 16 countries in Europe during 2010-2011. A total of 52.4% of MDR TB patients had never been treated for TB, which suggests primary transmission of MDR M. tuberculosis. At initiation of treatment for MDR TB, 59.7% of M. tuberculosis strains tested were resistant to pyrazinamide, 51.1% were resistant to >1 second-line drug, 26.6% were resistant to second-line injectable drugs, 17.6% were resistant to fuoroquinolones, and 6.8% were extensively drug resistant. Previous treatment for TB was the strongest risk factor for MDR TB. High levels of primary transmission and advanced resistance to second-line drugs characterize MDR TB cases in Europe.

AB - Drug-resistant Mycobacterium tuberculosis is challenging elimination of tuberculosis (TB). We evaluated risk factors for TB and levels of second-line drug resistance in M. tuberculosis in patients in Europe with multidrug-resistant (MDR) TB. A total of 380 patients with MDR TB and 376 patients with non-MDR TB were enrolled at 23 centers in 16 countries in Europe during 2010-2011. A total of 52.4% of MDR TB patients had never been treated for TB, which suggests primary transmission of MDR M. tuberculosis. At initiation of treatment for MDR TB, 59.7% of M. tuberculosis strains tested were resistant to pyrazinamide, 51.1% were resistant to >1 second-line drug, 26.6% were resistant to second-line injectable drugs, 17.6% were resistant to fuoroquinolones, and 6.8% were extensively drug resistant. Previous treatment for TB was the strongest risk factor for MDR TB. High levels of primary transmission and advanced resistance to second-line drugs characterize MDR TB cases in Europe.

UR - https://www.scopus.com/pages/publications/84923127789

U2 - 10.3201/eid2103.141343

DO - 10.3201/eid2103.141343

M3 - Article

C2 - 25693485

AN - SCOPUS:84923127789

SN - 1080-6040

VL - 21

SP - 409

EP - 416

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 3

ER -

Multidrug-resistant tuberculosis in europe, 2010-2011

Abstract

Bibliographical note

UN SDGs

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