TY - JOUR
T1 - MTBVAC induces superior antibody titers and IgG avidity compared to BCG vaccination in non-human primates
AU - Peralta-Álvarez, Marco Polo
AU - Downward, Keya
AU - White, Andrew
AU - Redondo Azema, Hugo
AU - Sibley, Laura
AU - Sarfas, Charlotte
AU - Morrison, Alexandra
AU - Dennis, Mike
AU - Diaz-Santana, Delia
AU - Harris, Stephanie A.
AU - Li, Shuailin
AU - Puentes, Eugenia
AU - Aguilo, Nacho
AU - Martin, Carlos
AU - Sharpe, Sally
AU - McShane, Helen
AU - Tanner, Rachel
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/12
Y1 - 2024/12
N2 - The only currently licensed vaccine against tuberculosis (TB), Bacille Calmette Guérin (BCG), is insufficient to control the epidemic. MTBVAC is a live attenuated strain of Mycobacterium tuberculosis (M.tb) and is one the most advanced TB vaccine candidates in the pipeline. It is more efficacious than BCG in preclinical models including non-human primates (NHPs), and has demonstrated safety and immunogenicity in human populations. To better understand the immune mechanisms underlying the superior efficacy conferred by MTBVAC, we characterized M.tb-specific antibody responses in NHPs vaccinated with either BCG or MTBVAC. MTBVAC vaccination induced higher titers of IgG, IgM and IgA, and higher avidity IgG compared with BCG vaccination. IgG avidity correlated with protection following M.tb challenge in the same animals, validating the association previously reported between this measure and protection in the context of intravenous BCG vaccination, suggesting that IgG avidity may represent a relevant marker or correlate of protection from TB.
AB - The only currently licensed vaccine against tuberculosis (TB), Bacille Calmette Guérin (BCG), is insufficient to control the epidemic. MTBVAC is a live attenuated strain of Mycobacterium tuberculosis (M.tb) and is one the most advanced TB vaccine candidates in the pipeline. It is more efficacious than BCG in preclinical models including non-human primates (NHPs), and has demonstrated safety and immunogenicity in human populations. To better understand the immune mechanisms underlying the superior efficacy conferred by MTBVAC, we characterized M.tb-specific antibody responses in NHPs vaccinated with either BCG or MTBVAC. MTBVAC vaccination induced higher titers of IgG, IgM and IgA, and higher avidity IgG compared with BCG vaccination. IgG avidity correlated with protection following M.tb challenge in the same animals, validating the association previously reported between this measure and protection in the context of intravenous BCG vaccination, suggesting that IgG avidity may represent a relevant marker or correlate of protection from TB.
UR - http://www.scopus.com/inward/record.url?scp=85209766830&partnerID=8YFLogxK
U2 - 10.1038/s41541-024-01009-5
DO - 10.1038/s41541-024-01009-5
M3 - Article
AN - SCOPUS:85209766830
SN - 2059-0105
VL - 9
JO - npj Vaccines
JF - npj Vaccines
IS - 1
M1 - 230
ER -
