Mpox diagnostics: Review of current and emerging technologies

Chuan Kok Lim; Jason Roberts; Michael Moso; Kwee Chin Liew; Mona L. Taouk; Eloise Williams; Thomas Tran; Eike Steinig; Leon Caly; Deborah Ann Williamson

doi:10.1002/jmv.28429

Mpox diagnostics: Review of current and emerging technologies

Chuan Kok Lim^*, Jason Roberts, Michael Moso, Kwee Chin Liew, Mona L. Taouk, Eloise Williams, Thomas Tran, Eike Steinig, Leon Caly, Deborah Ann Williamson

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

45 Citations (Scopus)

Abstract

Mpox is a zoonotic disease caused by monkeypox virus (MPXV) from the Orthopoxvirus genus. Unprecedented transmission events have led to more than 70 000 cases reported worldwide by October 2022. The change in mpox epidemiology has raised concerns of its ability to establish endemicity beyond its traditional geographical locations. In this review, we discuss the current understanding of mpox virology and viral dynamics that are relevant to mpox diagnostics. A synopsis of the traditional and emerging laboratory technologies useful for MPXV detection and in guiding “elimination” strategies is outlined in this review. Importantly, development in MPXV genomics has rapidly advanced our understanding of the role of viral evolution and adaptation in the current outbreak.

Original language	English
Article number	e28429
Journal	Journal of Medical Virology
Volume	95
Issue number	1
DOIs	https://doi.org/10.1002/jmv.28429
Publication status	Published - Jan 2023
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2022 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC.

Keywords

diagnostics
genomics
monkeypox
mpox
orthopoxvirus
serology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/jmv.28429

Cite this

@article{a5c4a6d2739143889773567afa05db21,

title = "Mpox diagnostics: Review of current and emerging technologies",

abstract = "Mpox is a zoonotic disease caused by monkeypox virus (MPXV) from the Orthopoxvirus genus. Unprecedented transmission events have led to more than 70 000 cases reported worldwide by October 2022. The change in mpox epidemiology has raised concerns of its ability to establish endemicity beyond its traditional geographical locations. In this review, we discuss the current understanding of mpox virology and viral dynamics that are relevant to mpox diagnostics. A synopsis of the traditional and emerging laboratory technologies useful for MPXV detection and in guiding “elimination” strategies is outlined in this review. Importantly, development in MPXV genomics has rapidly advanced our understanding of the role of viral evolution and adaptation in the current outbreak.",

keywords = "diagnostics, genomics, monkeypox, mpox, orthopoxvirus, serology",

author = "Lim, {Chuan Kok} and Jason Roberts and Michael Moso and Liew, {Kwee Chin} and Taouk, {Mona L.} and Eloise Williams and Thomas Tran and Eike Steinig and Leon Caly and Williamson, {Deborah Ann}",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC.",

year = "2023",

month = jan,

doi = "10.1002/jmv.28429",

language = "English",

volume = "95",

journal = "Journal of Medical Virology",

issn = "0146-6615",

publisher = "John Wiley and Sons Inc.",

number = "1",

}

TY - JOUR

T1 - Mpox diagnostics

T2 - Review of current and emerging technologies

AU - Lim, Chuan Kok

AU - Roberts, Jason

AU - Moso, Michael

AU - Liew, Kwee Chin

AU - Taouk, Mona L.

AU - Williams, Eloise

AU - Tran, Thomas

AU - Steinig, Eike

AU - Caly, Leon

AU - Williamson, Deborah Ann

PY - 2023/1

Y1 - 2023/1

N2 - Mpox is a zoonotic disease caused by monkeypox virus (MPXV) from the Orthopoxvirus genus. Unprecedented transmission events have led to more than 70 000 cases reported worldwide by October 2022. The change in mpox epidemiology has raised concerns of its ability to establish endemicity beyond its traditional geographical locations. In this review, we discuss the current understanding of mpox virology and viral dynamics that are relevant to mpox diagnostics. A synopsis of the traditional and emerging laboratory technologies useful for MPXV detection and in guiding “elimination” strategies is outlined in this review. Importantly, development in MPXV genomics has rapidly advanced our understanding of the role of viral evolution and adaptation in the current outbreak.

AB - Mpox is a zoonotic disease caused by monkeypox virus (MPXV) from the Orthopoxvirus genus. Unprecedented transmission events have led to more than 70 000 cases reported worldwide by October 2022. The change in mpox epidemiology has raised concerns of its ability to establish endemicity beyond its traditional geographical locations. In this review, we discuss the current understanding of mpox virology and viral dynamics that are relevant to mpox diagnostics. A synopsis of the traditional and emerging laboratory technologies useful for MPXV detection and in guiding “elimination” strategies is outlined in this review. Importantly, development in MPXV genomics has rapidly advanced our understanding of the role of viral evolution and adaptation in the current outbreak.

KW - diagnostics

KW - genomics

KW - monkeypox

KW - mpox

KW - orthopoxvirus

KW - serology

UR - http://www.scopus.com/inward/record.url?scp=85145938866&partnerID=8YFLogxK

U2 - 10.1002/jmv.28429

DO - 10.1002/jmv.28429

M3 - Review article

C2 - 36571266

AN - SCOPUS:85145938866

SN - 0146-6615

VL - 95

JO - Journal of Medical Virology

JF - Journal of Medical Virology

IS - 1

M1 - e28429

ER -

Mpox diagnostics: Review of current and emerging technologies

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this