Morphological three-dimensional analysis of papillary muscles in borderline left ventricles

Mari N. Velasco Forte, Mohamed Nassar, Nick Byrne, Miguel Silva Vieira, Israel V. Pérez, Bram Ruijsink, John Simpson, Tarique Hussain*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective Mitral valve anatomy has a significant impact on potential surgical options for patients with hypoplastic or borderline left ventricle. Papillary muscle morphology is a major component regarding this aspect. The purpose of this study was to use cardiac magnetic resonance to describe the differences in papillary muscle anatomy between normal, borderline, and hypoplastic left ventricles. Methods We carried out a retrospective, observational cardiac magnetic resonance study of children (median age 5.36 years) with normal (n=30), borderline (n=22), or hypoplastic (n=13) left ventricles. Borderline and hypoplastic cases had undergone an initial hybrid procedure. Morphological features of the papillary muscles, location, and arrangement were analysed and compared across groups. Results All normal ventricles had two papillary muscles with narrow pedicles; however, 18% of borderline and 46% of hypoplastic cases had a single papillary muscle, usually the inferomedial type. In addition, in borderline or hypoplastic ventricles, the supporting pedicle occasionally displayed a wide insertion along the ventricular wall. The length ratio of the superolateral support was significantly different between groups (normal: 0.46±0.08; borderline: 0.39±0.07; hypoplastic: 0.36±0.1; p=0.009). No significant difference, however, was found when analysing the inferomedial type (0.42±0.09; 0.38±0.07; 0.39±0.22, p=0.39). The angle subtended between supports was also similar among groups (113°±17°; 111°±51° and 114°±57°; p=0.99). A total of eight children with borderline left ventricle underwent biventricular repair. There were no significant differentiating features for papillary muscle morphology in this subgroup. Conclusions The superolateral support can be shorter or absent in borderline or hypoplastic left ventricle cases. The papillary muscle pedicles in these patients often show a broad insertion. These changes have important implications on surgical options and should be described routinely.

Original languageEnglish
Pages (from-to)1369-1376
Number of pages8
JournalCardiology in the Young
Volume27
Issue number7
DOIs
Publication statusPublished - 1 Sep 2017
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by the Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy's & St Thomas' NHS Foundation Trust in partnership with King's College London and King's College Hospital NHS Foundation Trust. The Division of Biomedical Engineering & Cardiovascular Imaging is part of the Centre of Excellence in Medical Engineering and is funded by the Welcome Trust and EPSRC (grant numberWT 088641/Z/09/Z). King's College London is a British Heart Foundation centre of excellence funded by the British Heart Foundation award RE/08/003.

Publisher Copyright:
© 2017 Cambridge University Press.

Keywords

  • borderline left ventricle
  • cardiac magnetic resonance
  • Hypoplastic left heart syndrome
  • papillary muscles

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