Monte Carlo modelling of an x-ray chamber for providing inactivation exposures to viruses

J. S. Eakins*, B. Afrough, R. Hewson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


The Monte Carlo radiation transport code MCNP6 has been used to model dosimetry for biological pathogen samples placed within a MultiRad 225 irradiation chamber, in order to inform virus deactivation protocols. Full characterisations of the photon spectra generated by the chamber’s x-ray tube were achieved for both 190 and 220 kV potentials, with and without aluminium and copper beam filters of different thicknesses. Dose rate maps to air and water within the chamber were then derived, along with corresponding conversion coefficient data. The maps were determined for samples located both on a shelf and on a dry ice refrigeration chamber, at different distances from the source. The potential depth-dose profiles through samples were also investigated. The optimum choice of filter for use in virus inactivation procedures will rely on a compromise between dose homogeneity and dose rate.

Original languageEnglish
Pages (from-to)962-981
Number of pages20
JournalJournal of Radiological Protection
Issue number4
Publication statusPublished - Dec 2021

Bibliographical note

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© 2021 Institute of Physics Publishing. All rights reserved.


  • Dose mapping
  • Field characterisation
  • Monte Carlo modelling
  • Virus inactivation
  • X-ray irradiation


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