Monitoring the safety of COVID-19 vaccination in pregnancy in the UK: A national study using the UK Obstetric Surveillance System (UKOSS), UK Teratology Information Service (UKTIS) and Vaccination in Pregnancy (VIP) safety monitoring systems

Jonathan L. Richardson; Sally Stephens; Lucy C. Chappell; Helen Campbell; Gayatri Amirthalingam; Shennae O’Boyle; Antoaneta Bukasa; Marian Knight; Kenneth K. Hodson

doi:10.1177/1753495X221076713

Monitoring the safety of COVID-19 vaccination in pregnancy in the UK: A national study using the UK Obstetric Surveillance System (UKOSS), UK Teratology Information Service (UKTIS) and Vaccination in Pregnancy (VIP) safety monitoring systems

Jonathan L. Richardson
, Sally Stephens
, Lucy C. Chappell
, Helen Campbell
, Gayatri Amirthalingam
, Shennae O’Boyle
, Antoaneta Bukasa
, Marian Knight
, Kenneth K. Hodson^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Background: COVID-19 vaccines are protective against disease. Pregnant women benefit from vaccination as they are at higher risk of poor maternal and neonatal outcomes following infection.

Methods: Following regulatory approval of two COVID-19 vaccines in the United Kingdom, a rapid national study of vaccination in pregnancy was instituted using three existing safety surveillance platforms: UKOSS, UKTIS and VIP. This preliminary report describes the data collected up to the 15^th June 2021.

Results: There were 971 reports of COVID-19 vaccination in the UKOSS/UKTIS (n = 493) and VIP (n = 478) monitoring systems describing 908 individual pregnancies. Pfizer-BioNTech mRNA vaccination was most common (n = 501, 55.2%), most women were vaccinated in their second or third trimester (n = 566, 62.3%), and were mainly vaccinated due to occupational infection risk (n = 577, 63.5%).

Conclusion: Obstetric outcome data will be obtained by December 2021. However, women should not delay vaccination whilst awaiting further safety data to emerge.

Original language	English
Article number	ARTN 1753495X221076713
Pages (from-to)	40-47
Number of pages	8
Journal	Obstetric Medicine
Volume	16
Issue number	1
Early online date	8 Feb 2022
DOIs	https://doi.org/10.1177/1753495X221076713
Publication status	E-pub ahead of print - 8 Feb 2022

Bibliographical note

Funding Information: No funding information.

Open Access: No Open Access licence.

Publisher Copyright: Copyright © 2022 by SAGE Publications

Citation: Richardson JL, Stephens S, Chappell LC, et al. Monitoring the safety of COVID-19 vaccination in pregnancy in the UK: A national study using the UK Obstetric Surveillance System (UKOSS), UK Teratology Information Service (UKTIS) and Vaccination in Pregnancy (VIP) safety monitoring systems. Obstetric Medicine. February 2022.

DOI: 10.1177/1753495X221076713

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

COVID-19 vaccine
SARS-coV-2
obstetric surveillance
pharmacovigilance
pregnancy
teratology
vaccination

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Richardson, J. L., Stephens, S., Chappell, L. C., Campbell, H., Amirthalingam, G., O’Boyle, S., Bukasa, A., Knight, M., & Hodson, K. K. (2022). Monitoring the safety of COVID-19 vaccination in pregnancy in the UK: A national study using the UK Obstetric Surveillance System (UKOSS), UK Teratology Information Service (UKTIS) and Vaccination in Pregnancy (VIP) safety monitoring systems. Obstetric Medicine, 16(1), 40-47. Article ARTN 1753495X221076713. Advance online publication. https://doi.org/10.1177/1753495X221076713

Richardson, Jonathan L. ; Stephens, Sally ; Chappell, Lucy C. et al. / Monitoring the safety of COVID-19 vaccination in pregnancy in the UK : A national study using the UK Obstetric Surveillance System (UKOSS), UK Teratology Information Service (UKTIS) and Vaccination in Pregnancy (VIP) safety monitoring systems. In: Obstetric Medicine. 2022 ; Vol. 16, No. 1. pp. 40-47.

@article{cc98a4a107ba4490ae70c43778667533,

title = "Monitoring the safety of COVID-19 vaccination in pregnancy in the UK: A national study using the UK Obstetric Surveillance System (UKOSS), UK Teratology Information Service (UKTIS) and Vaccination in Pregnancy (VIP) safety monitoring systems",

abstract = "Background: COVID-19 vaccines are protective against disease. Pregnant women benefit from vaccination as they are at higher risk of poor maternal and neonatal outcomes following infection. Methods: Following regulatory approval of two COVID-19 vaccines in the United Kingdom, a rapid national study of vaccination in pregnancy was instituted using three existing safety surveillance platforms: UKOSS, UKTIS and VIP. This preliminary report describes the data collected up to the 15th June 2021. Results: There were 971 reports of COVID-19 vaccination in the UKOSS/UKTIS (n = 493) and VIP (n = 478) monitoring systems describing 908 individual pregnancies. Pfizer-BioNTech mRNA vaccination was most common (n = 501, 55.2\%), most women were vaccinated in their second or third trimester (n = 566, 62.3\%), and were mainly vaccinated due to occupational infection risk (n = 577, 63.5\%). Conclusion: Obstetric outcome data will be obtained by December 2021. However, women should not delay vaccination whilst awaiting further safety data to emerge.",

keywords = "COVID-19 vaccine, SARS-coV-2, obstetric surveillance, pharmacovigilance, pregnancy, teratology, vaccination",

author = "Richardson, \{Jonathan L.\} and Sally Stephens and Chappell, \{Lucy C.\} and Helen Campbell and Gayatri Amirthalingam and Shennae O{\textquoteright}Boyle and Antoaneta Bukasa and Marian Knight and Hodson, \{Kenneth K.\}",

note = "Funding Information: No funding information. Open Access: No Open Access licence. Publisher Copyright: Copyright {\textcopyright} 2022 by SAGE Publications Citation: Richardson JL, Stephens S, Chappell LC, et al. Monitoring the safety of COVID-19 vaccination in pregnancy in the UK: A national study using the UK Obstetric Surveillance System (UKOSS), UK Teratology Information Service (UKTIS) and Vaccination in Pregnancy (VIP) safety monitoring systems. Obstetric Medicine. February 2022. DOI: 10.1177/1753495X221076713 ",

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Richardson, JL, Stephens, S, Chappell, LC, Campbell, H , Amirthalingam, G, O’Boyle, S, Bukasa, A, Knight, M & Hodson, KK 2022, 'Monitoring the safety of COVID-19 vaccination in pregnancy in the UK: A national study using the UK Obstetric Surveillance System (UKOSS), UK Teratology Information Service (UKTIS) and Vaccination in Pregnancy (VIP) safety monitoring systems', Obstetric Medicine, vol. 16, no. 1, ARTN 1753495X221076713, pp. 40-47. https://doi.org/10.1177/1753495X221076713

Monitoring the safety of COVID-19 vaccination in pregnancy in the UK: A national study using the UK Obstetric Surveillance System (UKOSS), UK Teratology Information Service (UKTIS) and Vaccination in Pregnancy (VIP) safety monitoring systems. / Richardson, Jonathan L.; Stephens, Sally; Chappell, Lucy C. et al.
In: Obstetric Medicine, Vol. 16, No. 1, ARTN 1753495X221076713, 08.02.2022, p. 40-47.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Monitoring the safety of COVID-19 vaccination in pregnancy in the UK

T2 - A national study using the UK Obstetric Surveillance System (UKOSS), UK Teratology Information Service (UKTIS) and Vaccination in Pregnancy (VIP) safety monitoring systems

AU - Richardson, Jonathan L.

AU - Stephens, Sally

AU - Chappell, Lucy C.

AU - Campbell, Helen

AU - Amirthalingam, Gayatri

AU - O’Boyle, Shennae

AU - Bukasa, Antoaneta

AU - Knight, Marian

AU - Hodson, Kenneth K.

N1 - Funding Information: No funding information. Open Access: No Open Access licence. Publisher Copyright: Copyright © 2022 by SAGE Publications Citation: Richardson JL, Stephens S, Chappell LC, et al. Monitoring the safety of COVID-19 vaccination in pregnancy in the UK: A national study using the UK Obstetric Surveillance System (UKOSS), UK Teratology Information Service (UKTIS) and Vaccination in Pregnancy (VIP) safety monitoring systems. Obstetric Medicine. February 2022. DOI: 10.1177/1753495X221076713

PY - 2022/2/8

Y1 - 2022/2/8

N2 - Background: COVID-19 vaccines are protective against disease. Pregnant women benefit from vaccination as they are at higher risk of poor maternal and neonatal outcomes following infection. Methods: Following regulatory approval of two COVID-19 vaccines in the United Kingdom, a rapid national study of vaccination in pregnancy was instituted using three existing safety surveillance platforms: UKOSS, UKTIS and VIP. This preliminary report describes the data collected up to the 15th June 2021. Results: There were 971 reports of COVID-19 vaccination in the UKOSS/UKTIS (n = 493) and VIP (n = 478) monitoring systems describing 908 individual pregnancies. Pfizer-BioNTech mRNA vaccination was most common (n = 501, 55.2%), most women were vaccinated in their second or third trimester (n = 566, 62.3%), and were mainly vaccinated due to occupational infection risk (n = 577, 63.5%). Conclusion: Obstetric outcome data will be obtained by December 2021. However, women should not delay vaccination whilst awaiting further safety data to emerge.

AB - Background: COVID-19 vaccines are protective against disease. Pregnant women benefit from vaccination as they are at higher risk of poor maternal and neonatal outcomes following infection. Methods: Following regulatory approval of two COVID-19 vaccines in the United Kingdom, a rapid national study of vaccination in pregnancy was instituted using three existing safety surveillance platforms: UKOSS, UKTIS and VIP. This preliminary report describes the data collected up to the 15th June 2021. Results: There were 971 reports of COVID-19 vaccination in the UKOSS/UKTIS (n = 493) and VIP (n = 478) monitoring systems describing 908 individual pregnancies. Pfizer-BioNTech mRNA vaccination was most common (n = 501, 55.2%), most women were vaccinated in their second or third trimester (n = 566, 62.3%), and were mainly vaccinated due to occupational infection risk (n = 577, 63.5%). Conclusion: Obstetric outcome data will be obtained by December 2021. However, women should not delay vaccination whilst awaiting further safety data to emerge.

KW - COVID-19 vaccine

KW - SARS-coV-2

KW - obstetric surveillance

KW - pharmacovigilance

KW - pregnancy

KW - teratology

KW - vaccination

UR - https://www.scopus.com/pages/publications/85124872483

U2 - 10.1177/1753495X221076713

DO - 10.1177/1753495X221076713

M3 - Article

AN - SCOPUS:85124872483

SN - 1753-495X

VL - 16

SP - 40

EP - 47

JO - Obstetric Medicine

JF - Obstetric Medicine

IS - 1

M1 - ARTN 1753495X221076713

ER -

Richardson JL, Stephens S, Chappell LC, Campbell H , Amirthalingam G, O’Boyle S et al. Monitoring the safety of COVID-19 vaccination in pregnancy in the UK: A national study using the UK Obstetric Surveillance System (UKOSS), UK Teratology Information Service (UKTIS) and Vaccination in Pregnancy (VIP) safety monitoring systems. Obstetric Medicine. 2022 Feb 8;16(1):40-47. ARTN 1753495X221076713. Epub 2022 Feb 8. doi: 10.1177/1753495X221076713

Monitoring the safety of COVID-19 vaccination in pregnancy in the UK: A national study using the UK Obstetric Surveillance System (UKOSS), UK Teratology Information Service (UKTIS) and Vaccination in Pregnancy (VIP) safety monitoring systems

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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