Molecular mechanisms of radiation oncogenesis

R. Cox*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    42 Citations (Scopus)

    Abstract

    Resolving the molecular mechanisms of radiation oncogenesis represents an important but daunting challenge in radiation research. This brief review outlines the principal oncogenic mechanisms that need to be considered in the context of radiation effects on the genome, how these might relate to specific gene and chromosomal changes relevant to neoplasia and the possible implications of such knowledge for the modelling of cancer risk. The long-term application of this mechanistic knowledge to the determination of tumour causality and for the assessment of individual cancer risk is also briefly discussed.

    Original languageEnglish
    Pages (from-to)57-64
    Number of pages8
    JournalInternational Journal of Radiation Biology
    Volume65
    Issue number1
    DOIs
    Publication statusPublished - 1994

    Bibliographical note

    Funding Information:
    Work on radiation oncogenesis in the authors laboratory is partly supported by the Commission of the European Communities .

    Copyright:
    Copyright 2014 Elsevier B.V., All rights reserved.

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