TY - JOUR
T1 - Molecular characteristics and epidemiology of meningococcal carriage, Burkina Faso, 2003
AU - Mueller, Judith E.
AU - Sangaré, Lassana
AU - Njanpop-Lafourcade, Berthe Marie
AU - Tarnagda, Zekiba
AU - Traoré, Yves
AU - Yaro, Seydou
AU - Borrow, Raymond
AU - Gessner, Bradford D.
AU - Nicolas, Pierre
PY - 2007/6
Y1 - 2007/6
N2 - To describe Neisseria meningitidis strains in the African meningitis belt in 2003, we obtained 2,389 oropharyngeal swabs at 5 monthly visits a representative population sample (age range 4-29 years) in Bobo-Dioulasso, Burkina Faso. A total of 152 carriage isolates were grouped, sero-typed, and genotyped. Most isolates were NG:NT:NST sequence type (ST) 192 (63% of all N. meningitidis), followed by W135:2a:P1.5,2 of ST-11 (16%) and NG:15:P1.6 of ST-198 (12%). We also found ST-2881 (W135:NT:P1.5,2), ST-751 (X:NT:P1.5), and ST-4375 (Y:14:P1.5,2) but not sero-groups A or C. Estimated average duration of carriage was 30 days (95% confidence interval 24-36 days). In the context of endemic group W135 and meningococcal A disease, we found substantial diversity in strains carried, including all strains currently involved in meningitis in this population, except for serogroup A. These findings show the need for large samples and a longitudinal design for N. meningitidis serogroup A carriage studies.
AB - To describe Neisseria meningitidis strains in the African meningitis belt in 2003, we obtained 2,389 oropharyngeal swabs at 5 monthly visits a representative population sample (age range 4-29 years) in Bobo-Dioulasso, Burkina Faso. A total of 152 carriage isolates were grouped, sero-typed, and genotyped. Most isolates were NG:NT:NST sequence type (ST) 192 (63% of all N. meningitidis), followed by W135:2a:P1.5,2 of ST-11 (16%) and NG:15:P1.6 of ST-198 (12%). We also found ST-2881 (W135:NT:P1.5,2), ST-751 (X:NT:P1.5), and ST-4375 (Y:14:P1.5,2) but not sero-groups A or C. Estimated average duration of carriage was 30 days (95% confidence interval 24-36 days). In the context of endemic group W135 and meningococcal A disease, we found substantial diversity in strains carried, including all strains currently involved in meningitis in this population, except for serogroup A. These findings show the need for large samples and a longitudinal design for N. meningitidis serogroup A carriage studies.
UR - http://www.scopus.com/inward/record.url?scp=34250011957&partnerID=8YFLogxK
U2 - 10.3201/eid1306.061395
DO - 10.3201/eid1306.061395
M3 - Article
C2 - 17553222
AN - SCOPUS:34250011957
SN - 1080-6040
VL - 13
SP - 847
EP - 854
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 6
ER -
