Molecular characteristics and epidemiology of meningococcal carriage, Burkina Faso, 2003

Judith E. Mueller*, Lassana Sangaré, Berthe Marie Njanpop-Lafourcade, Zekiba Tarnagda, Yves Traoré, Seydou Yaro, Raymond Borrow, Bradford D. Gessner, Pierre Nicolas

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

To describe Neisseria meningitidis strains in the African meningitis belt in 2003, we obtained 2,389 oropharyngeal swabs at 5 monthly visits a representative population sample (age range 4-29 years) in Bobo-Dioulasso, Burkina Faso. A total of 152 carriage isolates were grouped, sero-typed, and genotyped. Most isolates were NG:NT:NST sequence type (ST) 192 (63% of all N. meningitidis), followed by W135:2a:P1.5,2 of ST-11 (16%) and NG:15:P1.6 of ST-198 (12%). We also found ST-2881 (W135:NT:P1.5,2), ST-751 (X:NT:P1.5), and ST-4375 (Y:14:P1.5,2) but not sero-groups A or C. Estimated average duration of carriage was 30 days (95% confidence interval 24-36 days). In the context of endemic group W135 and meningococcal A disease, we found substantial diversity in strains carried, including all strains currently involved in meningitis in this population, except for serogroup A. These findings show the need for large samples and a longitudinal design for N. meningitidis serogroup A carriage studies.

Original languageEnglish
Pages (from-to)847-854
Number of pages8
JournalEmerging Infectious Diseases
Volume13
Issue number6
DOIs
Publication statusPublished - Jun 2007

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