Modelling the impact of a combined varicella and zoster vaccination programme on the epidemiology of varicella zoster virus in England

Albert Jan Van Hoek*, Alessia Melegaro, Emelio Zagheni, W. John Edmunds, Nigel Gay

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    91 Citations (Scopus)


    This study updates previous work on modelling the incidence of varicella and Herpes Zoster (HZ) following the introduction of childhood vaccination. The updated model includes new data on age-specific contact patterns, as well as data on the efficacy of zoster vaccination in the elderly and allows for HZ among vaccinees. The current study also looks at two-dose varicella childhood programmes, and assesses the combined impact of varicella vaccination in childhood and zoster vaccination of the elderly. The results suggest that a two-dose schedule is likely to reduce the incidence of varicella to very low levels, provided first dose coverage is around 90% and second dose coverage is in excess of 70%. Single dose varicella vaccination programmes are expected to result in large numbers of breakthrough cases. Childhood vaccination is expected to increase the incidence of zoster for more than 40 years after introduction of the programme, the magnitude of this increase being influenced primarily by the duration of boosting following exposure to the varicella zoster virus. Though this increase in zoster incidence can be partly offset by vaccination of the elderly, the effectiveness of this combined strategy is limited, as much of the increase occurs in those adults too young to be vaccinated. Childhood vaccination at intermediate levels of coverage (70% and 60% for first and second dose coverage respectively) is expected to lead to an increase in adult varicella. At high coverage (90% and 80% coverage) this is unlikely to be the case. These results will be used to inform a cost-effectiveness analysis of combined varicella and zoster vaccination programmes.

    Original languageEnglish
    Pages (from-to)2411-2420
    Number of pages10
    Issue number13
    Publication statusPublished - 16 Mar 2011

    Bibliographical note

    Funding Information:
    This research was partly funded by POLYMOD, a European Commission project funded within the Sixth Framework Programme, contract number: SSP22-CT-2004-502084, and partly by a grant from the UK Department of Health Policy Research Programme (grant number: 039/0031). AM was also partially funded by ECDC GRANT/2009/002. The views expressed in the publication are those of the authors and not necessarily those of the Department of Health.


    • Chickenpox
    • Herpes Zoster
    • Infectious disease modelling
    • Shingles
    • Vaccination
    • Varicella zoster


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