Modelling of DNA breaks and the formation of chromosome aberrations

Alan Edwards; V. V. Moiseenko; H. Nikjoo

doi:10.1080/09553009414551741

Modelling of DNA breaks and the formation of chromosome aberrations

Alan Edwards^*, V. V. Moiseenko, H. Nikjoo

^*Corresponding author for this work

Public Health England

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

We present results of some calculations that convert double-strand breaks to dicentrics by means of a repair-misrepair model. The method uses Monte Carlo techniques to determine the positions of the double-strand breaks and to determine the dicentric yields for comparison with those obtained experimentally in human lymphocytes following irradiation in G₀. The model is able to describe the linear-quadratic curves of dicentric yield following low LET irradiation, but underpredicts by a factor of about 1.5-2.0 the high LET neutron curves. The effects of including corrections for interphase death are demonstrated. The reasons for the discrepancy at high LET are discussed and suggestions for an improvement to the fit are made.

Original language	English
Pages (from-to)	633-637
Number of pages	5
Journal	International Journal of Radiation Biology
Volume	66
Issue number	5
DOIs	https://doi.org/10.1080/09553009414551741
Publication status	Published - 1994

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AB - We present results of some calculations that convert double-strand breaks to dicentrics by means of a repair-misrepair model. The method uses Monte Carlo techniques to determine the positions of the double-strand breaks and to determine the dicentric yields for comparison with those obtained experimentally in human lymphocytes following irradiation in G0. The model is able to describe the linear-quadratic curves of dicentric yield following low LET irradiation, but underpredicts by a factor of about 1.5-2.0 the high LET neutron curves. The effects of including corrections for interphase death are demonstrated. The reasons for the discrepancy at high LET are discussed and suggestions for an improvement to the fit are made.

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Modelling of DNA breaks and the formation of chromosome aberrations

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