Abstract
Uranium trioxide, produced industrially, was administered to rats either by inhalation or direct injection of an aqueous suspension into the lungs. The results: 1. show that uranium was cleared rapidly from the lungs, mainly to the blood; 2. show that distribution of uranium among body tissues, and the fraction of the systemic content excreted in urine, was similar to that obtained for other transportable hexavalent uranium compounds; 3. suggest that urine monitoring data would be of more value than lung radioactivity counting measurements for assessing occupational human exposure; 4. indicate that for setting exposure limits by inhalation the uranium trioxide should be considered a highly transportable compound. Thus intakes by workers should be restricted to those recommended for short-term exposures and not those based on an annual limit.
Original language | English |
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Pages (from-to) | 563-572 |
Number of pages | 10 |
Journal | Human Toxicology |
Volume | 4 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1985 |