Menstrual irregularity and asthma and lung function

Francisco Gómez Real*, Cecilie Svanes, Ernst Reidar Omenaas, Josep Maria Antò, Estel Plana, Christer Janson, Deborah Jarvis, Elisabeth Zemp, Matthias Wjst, Bénédicte Leynaert, Jordi Sunyer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)


Background: Oligomenorrhea was associated with more asthma (Respiratory Health in Northern Europe study), but a possible association with lung function has not been investigated previously. Objective: To investigate whether oligomenorrhea was related to lung function and asthma, and whether body mass index and physical activity modified associations. Methods: Women age 28 to 44 years (n = 1631) participating in the European Community Respiratory Health Survey were included. Women who were taking exogenous sex hormones, were pregnant, or had recently given birth were excluded. Results: Long or irregular menstrual cycles were reported by 313 women (19%). Oligomenorrhea was significantly associated with more asthma symptoms (odds ratio [OR], 1.76; 95% CI, 1.29-2.40), allergic asthma (OR, 2.46; 95% CI, 1.43-4.23), and lower forced vital capacity (FVC; adjusted difference, 63 mL; 95% CI, -124 to -1). When excluding women using asthma medication, very lean women, or women exercising daily, these associations remained significant. Effects of oligomenorrhea were additive to those of body mass index (BMI) on asthma and FVC. Asthma symptoms increased significantly with BMI. FVC and FEV1 increased with BMI until 25 kg/m2 and thereafter decreased with increasing BMI. Excluding women exercising daily, asthma symptoms increased significantly with decreasing physical activity (OR, 1.09; 95% CI, 1.001-1.19) per category of physical activity) independently of oligomenorrhea. Among women exercising daily, oligomenorrhea predicted very high risk for asthma symptoms (OR, 12.6; 95% CI, 3.7-43). Conclusion: Women with oligomenorrhea have reduced lung function and more asthma, particularly allergic asthma, independent of BMI and physical activity. Airways pathology may have not only a hormonal but also a metabolic component. Clinical implications: Women with oligomenorrhea should be investigated with regard to asthma and lung function. Underlying metabolic disturbance should be considered in asthma.

Original languageEnglish
Pages (from-to)557-564
Number of pages8
JournalJournal of Allergy and Clinical Immunology
Issue number3
Publication statusPublished - Sep 2007
Externally publishedYes

Bibliographical note

Funding Information:
F.G.R. was supported exclusively by the Norwegian Research Council (grant NFR 161299/V50). ECRHS II was supported by the European Commission as part of their Quality of Life program. Bodies funding the local studies in ECRHS II are listed in this article's Online Repository at .


  • allergy
  • asthma
  • body mass index
  • insulin resistance
  • Irregular menstruation
  • lung function
  • oligomenorrhea
  • physical activity


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