Meningococcal vaccine antigen diversity in global databases

Carina Brehony*, D. M. Hill, J. Lucidarme, Raymond Borrow, M. C. Maiden

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


The lack of an anti-capsular vaccine against serogroup B meningococcal disease has necessitated the exploration of alternative vaccine candidates, mostly proteins exhibiting varying degrees of antigenic variation. Analysis of variants of antigen-encoding genes is facilitated by publicly accessible online sequence repositories, such as the Neisseria PubMLST database and the associated Meningitis Research Foundation Meningococcus Genome Library (MRF-MGL). We investigated six proposed meningococcal vaccine formulations by deducing the prevalence of their components in the isolates represented in these repositories. Despite high diversity, a limited number of antigenic variants of each of the vaccine antigens were prevalent, with strong associations of particular variant combinations with given serogroups and genotypes. In the MRF-MGL and globally, the highest levels of identical sequences were observed with multicomponent/multivariant vaccines. Our analyses further demonstrated that certain combinations of antigen variants were prevalent over periods of decades in widely differing locations, indicating that vaccine formulations containing a judicious choice of antigen variants have potential for long-term protection across geographic regions. The data further indicated that formulations with multiple variants would be especially relevant at times of low disease incidence, as relative diversity was higher. Continued surveillance is required to monitor the changing prevalence of these vaccine antigens.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
Issue number49
Publication statusPublished - 10 Dec 2015

Bibliographical note

Publisher Copyright:
© 2015, European Centre for Disease Prevention and Control (ECDC). All rights reserved.


Dive into the research topics of 'Meningococcal vaccine antigen diversity in global databases'. Together they form a unique fingerprint.

Cite this