Meningococcal serogroup A, B, C, W, X, and Y serum bactericidal antibody assays

Jay Lucidarme; Jennifer Louth; Kelly Townsend-Payne; Raymond Borrow

doi:10.1007/978-1-4939-9202-7_12

Meningococcal serogroup A, B, C, W, X, and Y serum bactericidal antibody assays

Jay Lucidarme, Jennifer Louth, Kelly Townsend-Payne, Raymond Borrow^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

4 Citations (Scopus)

Abstract

Serum bactericidal antibody (SBA) assays measure functional antibody titers against Neisseria meningitidis in sera. Induction of complement-dependent SBA after vaccination with meningococcal polysaccharide or conjugate or protein based vaccines is regarded as the surrogate of protection and thus acceptable evidence of the potential efficacy of these vaccines. This chapter discusses and details SBA assay protocols for measuring the complement-mediated lysis of serogroup A, B, C, W, X, and Y meningococci by human sera, for example, following vaccination or disease.

Original language	English
Title of host publication	Methods in Molecular Biology
Publisher	Humana Press Inc.
Pages	169-179
Number of pages	11
DOIs	https://doi.org/10.1007/978-1-4939-9202-7_12
Publication status	Published - 2019

Publication series

Name	Methods in Molecular Biology
Volume	1969
ISSN (Print)	1064-3745

Keywords

Bactericidal
Complement
Meningococcal
Neisseria meningitidis
Serum bactericidal antibody

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-1-4939-9202-7_12

Cite this

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abstract = "Serum bactericidal antibody (SBA) assays measure functional antibody titers against Neisseria meningitidis in sera. Induction of complement-dependent SBA after vaccination with meningococcal polysaccharide or conjugate or protein based vaccines is regarded as the surrogate of protection and thus acceptable evidence of the potential efficacy of these vaccines. This chapter discusses and details SBA assay protocols for measuring the complement-mediated lysis of serogroup A, B, C, W, X, and Y meningococci by human sera, for example, following vaccination or disease.",

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AU - Townsend-Payne, Kelly

AU - Borrow, Raymond

PY - 2019

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AB - Serum bactericidal antibody (SBA) assays measure functional antibody titers against Neisseria meningitidis in sera. Induction of complement-dependent SBA after vaccination with meningococcal polysaccharide or conjugate or protein based vaccines is regarded as the surrogate of protection and thus acceptable evidence of the potential efficacy of these vaccines. This chapter discusses and details SBA assay protocols for measuring the complement-mediated lysis of serogroup A, B, C, W, X, and Y meningococci by human sera, for example, following vaccination or disease.

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KW - Neisseria meningitidis

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T3 - Methods in Molecular Biology

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BT - Methods in Molecular Biology

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ER -

Meningococcal serogroup A, B, C, W, X, and Y serum bactericidal antibody assays

Abstract

Publication series

Keywords

UN SDGs

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