Meningococcal disease in North America: Updates from the Global Meningococcal Initiative

Edwin J. Asturias; Xilian Bai; Julie A. Bettinger; Ray Borrow; Delia Nais Castillo; Dominique A. Caugant; Grettel Chanto Chacon; Ener Cagri Dinleyici; Gabriela Echaniz-Aviles; Luis Garcia; Linda Glennie; Lee H. Harrison; Rebecca L. Howie; Mark Itsko; Jay Lucidarme; Jose Eduardo Oliva Marin; Henju Marjuki; Lucy A. McNamara; Mustapha M. Mustapha; Joan L. Robinson; Belkis Romeu; Manish Sadarangani; Xavier Sáez-Llorens; Marco A.P. Sáfadi; David S. Stephens; James M. Stuart; Muhamed Kheir Taha; Raymond S.W. Tsang; Julio Vazquez; Philippe De Wals

doi:10.1016/j.jinf.2022.10.022

Meningococcal disease in North America: Updates from the Global Meningococcal Initiative

Edwin J. Asturias, Xilian Bai, Julie A. Bettinger, Ray Borrow^*, Delia Nais Castillo, Dominique A. Caugant, Grettel Chanto Chacon, Ener Cagri Dinleyici, Gabriela Echaniz-Aviles, Luis Garcia, Linda Glennie, Lee H. Harrison, Rebecca L. Howie, Mark Itsko, Jay Lucidarme, Jose Eduardo Oliva Marin, Henju Marjuki, Lucy A. McNamara, Mustapha M. Mustapha, Joan L. RobinsonBelkis Romeu, Manish Sadarangani, Xavier Sáez-Llorens, Marco A.P. Sáfadi, David S. Stephens, James M. Stuart, Muhamed Kheir Taha, Raymond S.W. Tsang, Julio Vazquez, Philippe De Wals

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

11 Citations (Scopus)

Abstract

This review summarizes the recent Global Meningococcal Initiative (GMI) regional meeting, which explored meningococcal disease in North America. Invasive meningococcal disease (IMD) cases are documented through both passive and active surveillance networks. IMD appears to be decreasing in many areas, such as the Dominican Republic (2016: 18 cases; 2021: 2 cases) and Panama (2008: 1 case/100,000; 2021: <0.1 cases/100,000); however, there is notable regional and temporal variation. Outbreaks persist in at-risk subpopulations, such as people experiencing homelessness in the US and migrants in Mexico. The recent emergence of β-lactamase-positive and ciprofloxacin-resistant meningococci in the US is a major concern. While vaccination practices vary across North America, vaccine uptake remains relatively high. Monovalent and multivalent conjugate vaccines (which many countries in North America primarily use) can provide herd protection. However, there is no evidence that group B vaccines reduce meningococcal carriage. The coronavirus pandemic illustrates that following public health crises, enhanced surveillance of disease epidemiology and catch-up vaccine schedules is key. Whole genome sequencing is a key epidemiological tool for identifying IMD strain emergence and the evaluation of vaccine strain coverage. The Global Roadmap on Defeating Meningitis by 2030 remains a focus of the GMI.

Original language	English
Pages (from-to)	611-622
Number of pages	12
Journal	Journal of Infection
Volume	85
Issue number	6
DOIs	https://doi.org/10.1016/j.jinf.2022.10.022
Publication status	Published - Dec 2022

Bibliographical note

Publisher Copyright:
© 2022

Keywords

Antibiotic resistance
Meningitis
Meningococcal
Neisseria species
North America
Vaccination

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jinf.2022.10.022

Cite this

Asturias, E. J., Bai, X., Bettinger, J. A., Borrow, R., Castillo, D. N., Caugant, D. A., Chacon, G. C., Dinleyici, E. C., Echaniz-Aviles, G., Garcia, L., Glennie, L., Harrison, L. H., Howie, R. L., Itsko, M., Lucidarme, J., Marin, J. E. O., Marjuki, H., McNamara, L. A., Mustapha, M. M., ... De Wals, P. (2022). Meningococcal disease in North America: Updates from the Global Meningococcal Initiative. Journal of Infection, 85(6), 611-622. https://doi.org/10.1016/j.jinf.2022.10.022

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title = "Meningococcal disease in North America: Updates from the Global Meningococcal Initiative",

abstract = "This review summarizes the recent Global Meningococcal Initiative (GMI) regional meeting, which explored meningococcal disease in North America. Invasive meningococcal disease (IMD) cases are documented through both passive and active surveillance networks. IMD appears to be decreasing in many areas, such as the Dominican Republic (2016: 18 cases; 2021: 2 cases) and Panama (2008: 1 case/100,000; 2021: <0.1 cases/100,000); however, there is notable regional and temporal variation. Outbreaks persist in at-risk subpopulations, such as people experiencing homelessness in the US and migrants in Mexico. The recent emergence of β-lactamase-positive and ciprofloxacin-resistant meningococci in the US is a major concern. While vaccination practices vary across North America, vaccine uptake remains relatively high. Monovalent and multivalent conjugate vaccines (which many countries in North America primarily use) can provide herd protection. However, there is no evidence that group B vaccines reduce meningococcal carriage. The coronavirus pandemic illustrates that following public health crises, enhanced surveillance of disease epidemiology and catch-up vaccine schedules is key. Whole genome sequencing is a key epidemiological tool for identifying IMD strain emergence and the evaluation of vaccine strain coverage. The Global Roadmap on Defeating Meningitis by 2030 remains a focus of the GMI.",

keywords = "Antibiotic resistance, Meningitis, Meningococcal, Neisseria species, North America, Vaccination",

author = "Asturias, {Edwin J.} and Xilian Bai and Bettinger, {Julie A.} and Ray Borrow and Castillo, {Delia Nais} and Caugant, {Dominique A.} and Chacon, {Grettel Chanto} and Dinleyici, {Ener Cagri} and Gabriela Echaniz-Aviles and Luis Garcia and Linda Glennie and Harrison, {Lee H.} and Howie, {Rebecca L.} and Mark Itsko and Jay Lucidarme and Marin, {Jose Eduardo Oliva} and Henju Marjuki and McNamara, {Lucy A.} and Mustapha, {Mustapha M.} and Robinson, {Joan L.} and Belkis Romeu and Manish Sadarangani and Xavier S{\'a}ez-Llorens and S{\'a}fadi, {Marco A.P.} and Stephens, {David S.} and Stuart, {James M.} and Taha, {Muhamed Kheir} and Tsang, {Raymond S.W.} and Julio Vazquez and {De Wals}, Philippe",

note = "Publisher Copyright: {\textcopyright} 2022",

year = "2022",

month = dec,

doi = "10.1016/j.jinf.2022.10.022",

language = "English",

volume = "85",

pages = "611--622",

journal = "Journal of Infection",

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Asturias, EJ, Bai, X, Bettinger, JA, Borrow, R, Castillo, DN, Caugant, DA, Chacon, GC, Dinleyici, EC, Echaniz-Aviles, G, Garcia, L, Glennie, L, Harrison, LH, Howie, RL, Itsko, M, Lucidarme, J, Marin, JEO, Marjuki, H, McNamara, LA, Mustapha, MM, Robinson, JL, Romeu, B, Sadarangani, M, Sáez-Llorens, X, Sáfadi, MAP, Stephens, DS, Stuart, JM, Taha, MK, Tsang, RSW, Vazquez, J & De Wals, P 2022, 'Meningococcal disease in North America: Updates from the Global Meningococcal Initiative', Journal of Infection, vol. 85, no. 6, pp. 611-622. https://doi.org/10.1016/j.jinf.2022.10.022

TY - JOUR

T1 - Meningococcal disease in North America

T2 - Updates from the Global Meningococcal Initiative

AU - Asturias, Edwin J.

AU - Bai, Xilian

AU - Bettinger, Julie A.

AU - Borrow, Ray

AU - Castillo, Delia Nais

AU - Caugant, Dominique A.

AU - Chacon, Grettel Chanto

AU - Dinleyici, Ener Cagri

AU - Echaniz-Aviles, Gabriela

AU - Garcia, Luis

AU - Glennie, Linda

AU - Harrison, Lee H.

AU - Howie, Rebecca L.

AU - Itsko, Mark

AU - Lucidarme, Jay

AU - Marin, Jose Eduardo Oliva

AU - Marjuki, Henju

AU - McNamara, Lucy A.

AU - Mustapha, Mustapha M.

AU - Robinson, Joan L.

AU - Romeu, Belkis

AU - Sadarangani, Manish

AU - Sáez-Llorens, Xavier

AU - Sáfadi, Marco A.P.

AU - Stephens, David S.

AU - Stuart, James M.

AU - Taha, Muhamed Kheir

AU - Tsang, Raymond S.W.

AU - Vazquez, Julio

AU - De Wals, Philippe

PY - 2022/12

Y1 - 2022/12

N2 - This review summarizes the recent Global Meningococcal Initiative (GMI) regional meeting, which explored meningococcal disease in North America. Invasive meningococcal disease (IMD) cases are documented through both passive and active surveillance networks. IMD appears to be decreasing in many areas, such as the Dominican Republic (2016: 18 cases; 2021: 2 cases) and Panama (2008: 1 case/100,000; 2021: <0.1 cases/100,000); however, there is notable regional and temporal variation. Outbreaks persist in at-risk subpopulations, such as people experiencing homelessness in the US and migrants in Mexico. The recent emergence of β-lactamase-positive and ciprofloxacin-resistant meningococci in the US is a major concern. While vaccination practices vary across North America, vaccine uptake remains relatively high. Monovalent and multivalent conjugate vaccines (which many countries in North America primarily use) can provide herd protection. However, there is no evidence that group B vaccines reduce meningococcal carriage. The coronavirus pandemic illustrates that following public health crises, enhanced surveillance of disease epidemiology and catch-up vaccine schedules is key. Whole genome sequencing is a key epidemiological tool for identifying IMD strain emergence and the evaluation of vaccine strain coverage. The Global Roadmap on Defeating Meningitis by 2030 remains a focus of the GMI.

AB - This review summarizes the recent Global Meningococcal Initiative (GMI) regional meeting, which explored meningococcal disease in North America. Invasive meningococcal disease (IMD) cases are documented through both passive and active surveillance networks. IMD appears to be decreasing in many areas, such as the Dominican Republic (2016: 18 cases; 2021: 2 cases) and Panama (2008: 1 case/100,000; 2021: <0.1 cases/100,000); however, there is notable regional and temporal variation. Outbreaks persist in at-risk subpopulations, such as people experiencing homelessness in the US and migrants in Mexico. The recent emergence of β-lactamase-positive and ciprofloxacin-resistant meningococci in the US is a major concern. While vaccination practices vary across North America, vaccine uptake remains relatively high. Monovalent and multivalent conjugate vaccines (which many countries in North America primarily use) can provide herd protection. However, there is no evidence that group B vaccines reduce meningococcal carriage. The coronavirus pandemic illustrates that following public health crises, enhanced surveillance of disease epidemiology and catch-up vaccine schedules is key. Whole genome sequencing is a key epidemiological tool for identifying IMD strain emergence and the evaluation of vaccine strain coverage. The Global Roadmap on Defeating Meningitis by 2030 remains a focus of the GMI.

KW - Antibiotic resistance

KW - Meningitis

KW - Meningococcal

KW - Neisseria species

KW - North America

KW - Vaccination

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U2 - 10.1016/j.jinf.2022.10.022

DO - 10.1016/j.jinf.2022.10.022

M3 - Review article

C2 - 36273639

AN - SCOPUS:85140982911

SN - 0163-4453

VL - 85

SP - 611

EP - 622

JO - Journal of Infection

JF - Journal of Infection

IS - 6

ER -

Meningococcal disease in North America: Updates from the Global Meningococcal Initiative

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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