Meningococcal carriage and immunity in western Burkina Faso, 2003

Seydou Yaro, Yves Traoré, Zekiba Tarnagda, Lassana Sangaré, Berthe Marie NjanpopLafourcade, Aly Drabo, Helen Findlow, Raymond Borrow, Pierre Nicolas, Bradford D. Gessner, Judith E. Mueller*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

A prospective carriage and serological study was conducted in Burkina Faso during the 2003 meningitis season, which was characterized by hyperendemic Neisseria meningitidis serogroup W135 (NmW135) and serogroup A (NmA) disease. Participants were evaluated five times at monthly intervals. In the presence of moderate NmW135 carriage, we found a low prevalence of putatively protective levels of specific immunoglobulin G (IgG) and serum bactericidal antibody (SBA) against NmW135. Specific IgG concentrations and SBA titers against NmA were relatively high in this recently vaccinated population, while no NmA carriage was detected. NmW135 carriage infrequently induced protective immunity against reference or homologous strains, while natural immunity against NmW135 was frequently lost. A vaccine that is effective against W135 will be beneficial for sub-Saharan Africa.

Original languageEnglish
Pages (from-to)A42-A46
JournalVaccine
Volume25
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 3 Sep 2007

Bibliographical note

Funding Information:
This work was supported by the Institut Pasteur and the Bill and Melinda Gates Foundation. The authors would like to thank the participants, the direction of the sanitary region of Bobo-Dioulasso, the field team under coordination and supervision of Ahmed Djihoud, Regina Idohou and Paulin Somda, and Florent Ky, Issaka Yougbaré, Oumarou Sanou and Maxime Kienou who led the laboratory work. Special acknowledgments are given to Isabelle Parent du Châtelet, Brian Greenwood, Arnaud Fontanet, and Montserrat Soriano-Gabarro for scientific advice.

Keywords

  • Carriage
  • Immunity
  • Neisseria meningitidis

Fingerprint

Dive into the research topics of 'Meningococcal carriage and immunity in western Burkina Faso, 2003'. Together they form a unique fingerprint.

Cite this