Meeting report narcolepsy and pandemic influenza vaccination: What we know and what we need to know before the next pandemic? A report from the 2nd IABS meeting

Kathryn Edwards*, Germaine Hanquet, Steve Black, Emmanuel Mignot, Christopher Jankosky, Tom Shimabukuro, Elizabeth Miller, Hanna Nohynek, Pieter Neels

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

A group of scientific and public health experts and key stakeholders convened to discuss the state of knowledge on the relationship between adjuvanted monovalent inactivated 2009 influenza A H1N1 vaccines used during the 2009 influenza pandemic and narcolepsy. There was consensus that an increased risk of narcolepsy was consistently observed after Pandemrix (AS03-adjuvanted) vaccine, but similar associations following Arepanrix (AS03-adjuvanted) or Focetria (MF59-adjuvanted) vaccines were not observed. Whether the differences are due to vaccine composition or other factors such as the timing of large-scale vaccination programs relative to H1N1pdm09 wild-type virus circulation in different geographic regions is not clear. The limitations of retrospective observational methodologies could also be contributing to some of the differences across studies. More basic and epidemiologic research is needed to further elucidate the association between adjuvanted influenza vaccine and narcolepsy and its mechanism and to inform planning and preparation for vaccination programs in advance of the next influenza pandemic.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalBiologicals
Volume60
DOIs
Publication statusPublished - Jul 2019

Bibliographical note

Funding Information:
The meeting was organized by IABS-EU in collaboration with Federal Agency for Medicines and Health Products (FAGG/AFMPS) with financial support from GlaxoSmithKline and Sanofi Pasteur.

Publisher Copyright:
© 2019

Keywords

  • Adjuvants
  • Antigen system 03 (AS03)
  • H1N1pdm09 influenza vaccines
  • Narcolepsy
  • Pandemic influenza
  • Pandemrix vaccine

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