Medication use in relation to noise from aircraft and road traffic in six European countries: Results of the HYENA study

Sarah Floud*, Federica Vigna-Taglianti, Anna Hansell, Marta Blangiardo, Danny Houthuijs, Oscar Breugelmans, Ennio Cadum, Wolfgang Babisch, Jenny Selander, Göran Pershagen, Maria Chiara Antoniotti, Salvatore Pisani, Konstantina Dimakopoulou, Alexandros S. Haralabidis, Venetia Velonakis, Lars Jarup

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

70 Citations (Scopus)


Objectives: Studies on the health effects of aircraft and road traffic noise exposure suggest excess risks of hypertension, cardiovascular disease and the use of sedatives and hypnotics. Our aim was to assess the use of medication in relation to noise from aircraft and road traffic. Methods: This cross-sectional study measured the use of prescribed antihypertensives, antacids, anxiolytics, hypnotics, antidepressants and antasthmatics in 4,861 persons living near seven airports in six European countries (UK, Germany, the Netherlands, Sweden, Italy, and Greece). Exposure was assessed using models with 1dB resolution (5dB for UK road traffic noise) and spatial resolution of 250x250m for aircraft and 10x10m for road traffic noise. Data were analysed using multilevel logistic regression, adjusting for potential confounders. Results: We found marked differences between countries in the effect of aircraft noise on antihypertensive use; for night-time aircraft noise, a 10dB increase in exposure was associated with ORs of 1.34 (95% CI 1.14 to1.57) for the UK and 1.19 (1.02 to 1.38) for the Netherlands but no significant associations were found for other countries. For day-time aircraft noise, excess risks were found for the UK (OR 1.35; CI: 1.13 to 1.60) but a risk deficit for Italy (OR 0.82; CI: 0.71 to 0.96). There was an excess risk of taking anxiolytic medication in relation to aircraft noise (OR 1.28; CI: 1.04 to 1.57 for daytime and OR 1.27; CI: 1.01 to 1.59 for night-time) which held across countries. We also found an association between exposure to 24hr road traffic noise and the use of antacids by men (OR 1.39; CI 1.11 to 1.74). Conclusion: Our results suggest an effect of aircraft noise on the use of antihypertensive medication, but this effect did not hold for all countries. Results were more consistent across countries for the increased use of anxiolytics in relation to aircraft noise.

Original languageEnglish
Pages (from-to)518-524
Number of pages7
JournalOccupational and Environmental Medicine
Issue number7
Publication statusPublished - Jul 2011
Externally publishedYes


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