TY - GEN
T1 - Mathematical modelling of near-infrared spectroscopy signals and intracranial pressure in brain-injured patients
AU - Highton, David
AU - Panovska-Griffiths, Jasmina
AU - Smith, Martin
AU - Elwell, Clare E.
PY - 2013
Y1 - 2013
N2 - Raised intracranial pressure (ICP) is a key concern following acute brain injury as it may be associated with cerebral hypoperfusion and poor outcome. In this research we describe a mathematical physiological model designed to interpret cerebral physiology from neuromonitoring: ICP, near-infrared spectroscopy and transcranial Doppler flow velocity. This aims to characterise the complex dynamics of cerebral compliance, cerebral blood volume, cerebral blood flow and their regulation in individual patients. Analysis of data from six brain-injured patients produces cohesive predictions of cerebral biomechanics suggesting reduced cerebral compliance, reduced volume compensation and impaired blood flow autoregulation. Patient-specific physiological modelling has the potential to predict the key biomechanical and haemodynamic changes following brain injury in individual patients, and might be used to inform individualised treatment strategies.
AB - Raised intracranial pressure (ICP) is a key concern following acute brain injury as it may be associated with cerebral hypoperfusion and poor outcome. In this research we describe a mathematical physiological model designed to interpret cerebral physiology from neuromonitoring: ICP, near-infrared spectroscopy and transcranial Doppler flow velocity. This aims to characterise the complex dynamics of cerebral compliance, cerebral blood volume, cerebral blood flow and their regulation in individual patients. Analysis of data from six brain-injured patients produces cohesive predictions of cerebral biomechanics suggesting reduced cerebral compliance, reduced volume compensation and impaired blood flow autoregulation. Patient-specific physiological modelling has the potential to predict the key biomechanical and haemodynamic changes following brain injury in individual patients, and might be used to inform individualised treatment strategies.
UR - http://www.scopus.com/inward/record.url?scp=84934434267&partnerID=8YFLogxK
U2 - 10.1007/978-1-4614-7411-1_46
DO - 10.1007/978-1-4614-7411-1_46
M3 - Conference contribution
C2 - 23852514
AN - SCOPUS:84934434267
SN - 9781461472568
T3 - Advances in Experimental Medicine and Biology
SP - 345
EP - 351
BT - Oxygen Transport to Tissue XXXV
PB - Springer New York LLC
ER -