Maternal vaccination: a review of current evidence and recommendations

Melanie Etti*, Anna Calvert, Eva Galiza, Suzy Lim, Asma Khalil, Kirsty Le Doare, Paul T. Heath

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Maternal vaccination is an effective means of protecting pregnant women, their fetuses, and infants from vaccine-preventable infections. Despite the availability of sufficient safety data to support the use of vaccines during pregnancy, maternal immunization remains an underutilized method of disease prevention, often because of concerns from both healthcare providers and pregnant women about vaccine safety. Such concerns have been reflected in the low uptake of the COVID-19 vaccine among pregnant women seen in many parts of the world. Here, we present an update of the current recommendations for the use of vaccines during pregnancy, including the evidence supporting the use of novel vaccine platforms. We also provide an overview of the data supporting the use of COVID-19 vaccines in pregnancy and an update of the status of vaccines that are currently under development for use in pregnant women.

Original languageEnglish
Pages (from-to)459-474
Number of pages16
JournalAmerican Journal of Obstetrics and Gynecology
Issue number4
Publication statusPublished - Apr 2022
Externally publishedYes

Bibliographical note

Funding Information:
P.T.H. reports grant funding to his institution from vaccine manufacturers, including Pfizer, Novavax, and Minervax. The other authors report no conflict of interest.

Publisher Copyright:
© 2021 Elsevier Inc.


  • COVID-19 vaccination
  • immunogenicity
  • maternal vaccination
  • neonates
  • safety


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