Management and outcome of bloodstream infections due to Candida species in England and Wales

C. C. Kibbler*, S. Seaton, R. A. Barnes, W. R. Gransden, R. E. Holliman, Elizabeth Johnson, J. D. Perry, D. J. Sullivan, J. A. Wilson

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    179 Citations (Scopus)

    Abstract

    This two-year prospective hospital population-based study of candidaemia is the first to be conducted in the UK. It was carried out on behalf on the British Society for Medical Mycology (BSMM) as part of the European Confederation of Medical Mycology (ECMM) epidemiological survey of candidaemia. Six hospitals in England and Wales acted as sentinel hospitals. Main outcome measures were hospital population-based incidence and 30-day mortality. There were 18.7 episodes of candidaemia per 100 000 finished consultant episodes or 3.0/100 000 bed days and 45.4% cases occurred in intensive care unit (ICU) patients. Candida albicans was isolated in 64.7% of confirmed cases. The majority of isolates were sensitive to standard antifungal agents, including fluconazole. The overall 30-day mortality was 26.4% and removal of the central venous catheter was associated with a significant reduction in mortality. In conclusion, the incidence of candidaemia in England and Wales is similar to that of the USA, the majority of isolates remain sensitive to commonly used antifungal agents and mortality associated with this infection appears to be falling.

    Original languageEnglish
    Pages (from-to)18-24
    Number of pages7
    JournalJournal of Hospital Infection
    Volume54
    Issue number1
    DOIs
    Publication statusPublished - May 2003

    Keywords

    • Antifungal therapy
    • Bloodstream infections
    • Candida albicans
    • Candidaemia
    • Epidemiology
    • Mortality

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