TY - JOUR
T1 - Major uropathogenic Escherichia coli strain isolated in the Northwest of England identified by multilocus sequence typing
AU - Siu, Ha Lau
AU - Reddy, Suganya
AU - Cheesbrough, John
AU - Bolton, Frederick J.
AU - Willshaw, Geraldine
AU - Cheasty, Tom
AU - Fox, Andrew J.
AU - Upton, Mathew
PY - 2008/3
Y1 - 2008/3
N2 - A total of 88 uropathogenic Escherichia coli isolates, including 68 isolates from urine and 20 isolates from blood, were characterized by multilocus sequence typing (MLST). MLST has identified an important genetic lineage of E. coli, designated sequence type 131 (ST-131), represented by 52 of these isolates, 51 of which were resistant to extended-spectrum cephalosporins. ST-131 appears to be a drug-resistant uropathogenic strain of E. coli responsible for causing urinary tract infections and bacteremia and is widely disseminated among both community and hospital patients from different geographical areas in the northwest of England. Application of MLST has helped to define the population biology which may underpin the epidemiology of pathogenic E. coli strains. The portability of MLST allows the accurate monitoring of this antibiotic-resistant uropathogenic strain of E. coli and will enhance surveillance for this important group of organisms.
AB - A total of 88 uropathogenic Escherichia coli isolates, including 68 isolates from urine and 20 isolates from blood, were characterized by multilocus sequence typing (MLST). MLST has identified an important genetic lineage of E. coli, designated sequence type 131 (ST-131), represented by 52 of these isolates, 51 of which were resistant to extended-spectrum cephalosporins. ST-131 appears to be a drug-resistant uropathogenic strain of E. coli responsible for causing urinary tract infections and bacteremia and is widely disseminated among both community and hospital patients from different geographical areas in the northwest of England. Application of MLST has helped to define the population biology which may underpin the epidemiology of pathogenic E. coli strains. The portability of MLST allows the accurate monitoring of this antibiotic-resistant uropathogenic strain of E. coli and will enhance surveillance for this important group of organisms.
UR - https://www.scopus.com/pages/publications/40749102940
U2 - 10.1128/JCM.02065-07
DO - 10.1128/JCM.02065-07
M3 - Article
C2 - 18199778
AN - SCOPUS:40749102940
SN - 0095-1137
VL - 46
SP - 1076
EP - 1081
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
IS - 3
ER -