Low serum serotype-specific pneumococcal antibody concentrations in young children with Haemophilus influenzae serotype b (Hib) vaccine failure

Shamez Ladhani*, Raymond Borrow, Paul T. Heath, Mary Ramsay, Robert Booy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Serotype-specific pneumococcal antibody concentrations were measured in 164 children with Hib vaccine failure prior to routine pneumococcal immunisation. Compared with age-matched controls, a higher proportion of cases had non-protective antibody concentrations (<0.35 μg/ml) for 7/9 (78%) serotypes tested among 2-4 year-olds, 4/9 (44%) among 5-7 year-olds, 1/9 (11%) among 8-11 year-olds and 0/9 (0%) among 12-15 year-olds (χ2 for trend = 14.0, p = 0.0002). Cases aged 2-4 years were also more likely to have non-protective antibody concentrations against more serotypes than controls, suggesting that children with Hib vaccine failure may have an intact but physiologically delayed ability to develop protective antibody concentrations against encapsulated organisms.

Original languageEnglish
Pages (from-to)4440-4444
Number of pages5
JournalVaccine
Volume28
Issue number28
DOIs
Publication statusPublished - 17 Jun 2010

Keywords

  • Conjugate vaccine failure
  • Hib antibody
  • Serotype-specific pneumococcal antibody

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