Low-field benchtop NMR spectroscopy as a potential non-stationary tool for point-of-care urinary metabolite tracking in diabetic conditions

Mark Edgar; Benita C. Percival; Miles Gibson; Fereshteh Jafari; Martin Grootveld

doi:10.1016/j.diabres.2020.108554

Low-field benchtop NMR spectroscopy as a potential non-stationary tool for point-of-care urinary metabolite tracking in diabetic conditions

Mark Edgar
, Benita C. Percival
, Miles Gibson
, Fereshteh Jafari
, Martin Grootveld^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

We describe the advantages and diagnostic/prognostic significance of low-field, near-portable benchtop NMR spectrometers for the multicomponent metabolomics analysis of targeted and untargeted urinary biomarkers (≥15) in type 2 diabetes patients. Implementation of these facilities at ‘point-of-care’ clinical sites may yield valuable advantages for the sequential monitoring of diabetic and prediabetic individuals.

Original language	English
Article number	108554
Journal	Diabetes Research and Clinical Practice
Volume	171
DOIs	https://doi.org/10.1016/j.diabres.2020.108554
Publication status	Published - Jan 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020

Keywords

Biomarkers
NMR-based metabolomics
Non-stationary benchtop 60 MHz NMR analysis
Prediabetes
Type 2 diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diabres.2020.108554

Cite this

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abstract = "We describe the advantages and diagnostic/prognostic significance of low-field, near-portable benchtop NMR spectrometers for the multicomponent metabolomics analysis of targeted and untargeted urinary biomarkers (≥15) in type 2 diabetes patients. Implementation of these facilities at {\textquoteleft}point-of-care{\textquoteright} clinical sites may yield valuable advantages for the sequential monitoring of diabetic and prediabetic individuals.",

keywords = "Biomarkers, NMR-based metabolomics, Non-stationary benchtop 60 MHz NMR analysis, Prediabetes, Type 2 diabetes",

author = "Mark Edgar and Percival, \{Benita C.\} and Miles Gibson and Fereshteh Jafari and Martin Grootveld",

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year = "2021",

month = jan,

doi = "10.1016/j.diabres.2020.108554",

language = "English",

volume = "171",

journal = "Diabetes Research and Clinical Practice",

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AU - Edgar, Mark

AU - Percival, Benita C.

AU - Gibson, Miles

AU - Jafari, Fereshteh

AU - Grootveld, Martin

PY - 2021/1

Y1 - 2021/1

N2 - We describe the advantages and diagnostic/prognostic significance of low-field, near-portable benchtop NMR spectrometers for the multicomponent metabolomics analysis of targeted and untargeted urinary biomarkers (≥15) in type 2 diabetes patients. Implementation of these facilities at ‘point-of-care’ clinical sites may yield valuable advantages for the sequential monitoring of diabetic and prediabetic individuals.

AB - We describe the advantages and diagnostic/prognostic significance of low-field, near-portable benchtop NMR spectrometers for the multicomponent metabolomics analysis of targeted and untargeted urinary biomarkers (≥15) in type 2 diabetes patients. Implementation of these facilities at ‘point-of-care’ clinical sites may yield valuable advantages for the sequential monitoring of diabetic and prediabetic individuals.

KW - Biomarkers

KW - NMR-based metabolomics

KW - Non-stationary benchtop 60 MHz NMR analysis

KW - Prediabetes

KW - Type 2 diabetes

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DO - 10.1016/j.diabres.2020.108554

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JO - Diabetes Research and Clinical Practice

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M1 - 108554

ER -

Low-field benchtop NMR spectroscopy as a potential non-stationary tool for point-of-care urinary metabolite tracking in diabetic conditions

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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